Improving the Compatibility of Diketopyrrolopyrrole (DPP) Semiconducting Polymers for Biological Interfacing by Lysine Attachment
Type
ArticleAuthors
du, weiyuan
ohayon, David
Combe, Craig
Mottier, Lorene
Maria, Iuliana P.
Ashraf, Raja
Fiumelli, Hubert

Inal, Sahika

McCulloch, Iain

KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Chemical Science Program
KAUST Solar Center (KSC)
Physical Science and Engineering (PSE) Division
KAUST Grant Number
OSR-2016-CRG5-3003Date
2018-08-17Online Publication Date
2018-08-17Print Publication Date
2018-09-11Permanent link to this record
http://hdl.handle.net/10754/628480
Metadata
Show full item recordAbstract
Organic semiconductors are being increasingly used for a variety of biological applications, such as biochemical sensors, drug delivery, and neural interfaces. However, the poor adhesion of cells to the typically hydrophobic, neutrally charged and low surface energy of semiconducting thin films limit their use in in vitro, cell integrated bioelectronic devices. In this work, we investigate the influence of lysine side chain units incorporated in a diketopyrrolopyrrole (DPP) semiconducting polymer on neural cell adhesion and growth, as well as evaluate their function in electrical devices. Synthesis of such biofunctionalized polymers obviates the need of biological coating steps while changing the surface physiochemistry, promising for applications in bioelectronics.Citation
Du W, Ohayon D, Combe C, Mottier L, Maria IP, et al. (2018) Improving the Compatibility of Diketopyrrolopyrrole Semiconducting Polymers for Biological Interfacing by Lysine Attachment. Chemistry of Materials. Available: http://dx.doi.org/10.1021/acs.chemmater.8b02804.Sponsors
We acknowledge funding from KAUST, as well as EPSRC Project EP/G037515/1, EP/M005143/1, ECFP7 Project SC2 (610115), for the financial support. D.O, S.I. and I.M. gratefully acknowledge financial support from the KAUST Office of Sponsored Research (OSR) under Award No. OSR-2016-CRG5-3003.Publisher
American Chemical Society (ACS)Journal
Chemistry of MaterialsAdditional Links
https://pubs.acs.org/doi/10.1021/acs.chemmater.8b02804ae974a485f413a2113503eed53cd6c53
10.1021/acs.chemmater.8b02804