Improving the Compatibility of Diketopyrrolopyrrole (DPP) Semiconducting Polymers for Biological Interfacing by Lysine Attachment
Maria, Iuliana P.
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Chemical Science Program
KAUST Solar Center (KSC)
Physical Science and Engineering (PSE) Division
KAUST Grant NumberOSR-2016-CRG5-3003
Online Publication Date2018-08-17
Print Publication Date2018-09-11
Permanent link to this recordhttp://hdl.handle.net/10754/628480
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AbstractOrganic semiconductors are being increasingly used for a variety of biological applications, such as biochemical sensors, drug delivery, and neural interfaces. However, the poor adhesion of cells to the typically hydrophobic, neutrally charged and low surface energy of semiconducting thin films limit their use in in vitro, cell integrated bioelectronic devices. In this work, we investigate the influence of lysine side chain units incorporated in a diketopyrrolopyrrole (DPP) semiconducting polymer on neural cell adhesion and growth, as well as evaluate their function in electrical devices. Synthesis of such biofunctionalized polymers obviates the need of biological coating steps while changing the surface physiochemistry, promising for applications in bioelectronics.
CitationDu W, Ohayon D, Combe C, Mottier L, Maria IP, et al. (2018) Improving the Compatibility of Diketopyrrolopyrrole Semiconducting Polymers for Biological Interfacing by Lysine Attachment. Chemistry of Materials. Available: http://dx.doi.org/10.1021/acs.chemmater.8b02804.
SponsorsWe acknowledge funding from KAUST, as well as EPSRC Project EP/G037515/1, EP/M005143/1, ECFP7 Project SC2 (610115), for the financial support. D.O, S.I. and I.M. gratefully acknowledge financial support from the KAUST Office of Sponsored Research (OSR) under Award No. OSR-2016-CRG5-3003.
PublisherAmerican Chemical Society (ACS)
JournalChemistry of Materials