Type
Book ChapterAuthors
Perez, Jose E.
Alsharif, Nouf

Martinez Banderas, Aldo

Othman, Basmah
Merzaban, Jasmeen

Ravasi, Timothy

Kosel, Jürgen

KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Chemical and Biological Engineering Program
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Electrical Engineering Program
Date
2018-07-25Permanent link to this record
http://hdl.handle.net/10754/628388
Metadata
Show full item recordAbstract
The specific use of engineered nanostructures in biomedical applications has become very attractive, due to their ability to interface and target specific cells and tissues to execute their functions. Additionally, there is continuous progress in research on new nanostructures with unique optical, magnetic, catalytic and electrochemical properties that can be exploited for therapeutic or diagnostic methods. On the other hand, as nanostructures become widely used in many different applications, the unspecific exposure of humans to them is also unavoidable. Therefore, studying and understanding the toxicity of such materials are of increasing importance. Previously published reviews regarding the toxicological effects of nanostructures focus mostly on the cytotoxicity of nanoparticles and their internalization, activated signaling pathways and cellular response. Here, the most recent studies on the invitro cytotoxicity of NPs, nanowires and nanorods for biomedical applications are reviewed and divided into two parts. The first part considers nonmagnetic metallic and magnetic nanostructures, while, the second part covers carbon structures and semiconductors. The factors influencing the toxicity of these nanostructures are elaborated to help elucidate the effects of these nanomaterials on cells, which is a prerequisite for their safe clinical use.Citation
Perez JE, Alsharif N, Martínez-Banderas AI, Othman B, Merzaban J, et al. (2018) Review of In Vitro Toxicity of Nanoparticles and Nanorods—Part 2. Cytotoxicity. Available: http://dx.doi.org/10.5772/intechopen.78616.Sponsors
Research reported in this publication was supported by the King Abdullah University of Science and Technology (KAUST).Publisher
IntechOpenJournal
CytotoxicityAdditional Links
https://www.intechopen.com/books/cytotoxicity/review-of-in-vitro-toxicity-of-nanoparticles-and-nanorods-part-2ae974a485f413a2113503eed53cd6c53
10.5772/intechopen.78616
Scopus Count
Except where otherwise noted, this item's license is described as This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.