Enzyme-Free Detection of Glucose with a Hybrid Conductive Gel Electrode
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Materials Science and Engineering Program
Online Publication Date2018-08-14
Print Publication Date2019-01
Permanent link to this recordhttp://hdl.handle.net/10754/628267
MetadataShow full item record
AbstractCurrent assays for glucose monitoring rely predominantly on glucose oxidation-catalyzing enzymes because of the high specificity of enzyme–substrate interactions. Enzymes are however expensive, suffer from instability during fabrication, operation, and storage, and necessitate complex procedures for integration with transducer materials. These challenges, rendering the enzyme-based sensors disadvantageous for routine glucose monitoring, can be overcome by nonenzymatic sensors. Here, for the enzyme-free detection of glucose, an electroactive gel is developed via one-pot polymerization. The functional material is a hybrid of the conducting polymer poly(3,4-ethylenedioxythiophene):polystyrenesulfonate and a polyacrylamide gel functionalized with phenylboronic acid. As an electrode, the gel exhibits a specific current response to glucose within the standard concentration range measured in the complex blood-like medium. When integrated as the lateral, micrometer-scale gate electrode of an organic electrochemical transistor (OECT), the channel current is proven to be sensitive to the presence of glucose in the measurement solution. The advantage of the OECT-based sensor compared to the amperometric electrode is its miniaturized form, amplified input signal as well the elimination of a reference electrode. Adaptable to different geometries, this conducting gel exhibits multifunctionality within its soft, gel-like architecture, that is, mixed ionic and electronic conductivity and glucose-specific electrical response.
CitationWustoni S, Savva A, Sun R, Bihar E, Inal S (2018) Enzyme-Free Detection of Glucose with a Hybrid Conductive Gel Electrode. Advanced Materials Interfaces: 1800928. Available: http://dx.doi.org/10.1002/admi.201800928.
SponsorsThe authors thank Nini Wei at Imaging and Characterization facilities at KAUST Core Labs for assisting with the FIB measurements. Figures 1a and 4a were created by Heno Hwang, scientific illustrator at King Abdullah University of Science and Technology (KAUST).
JournalAdvanced Materials Interfaces