Synthesis and Application of PN3P Cobalt Pincer Complex for Selective Hydrogenation of Nitriles to Secondary Imines and α -Alkylation of Nitriles with Alcohols
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AuthorsAl Dakhil, Abdullah
KAUST DepartmentPhysical Science and Engineering (PSE) Division
Embargo End Date2019-08-11
Permanent link to this recordhttp://hdl.handle.net/10754/628071
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Access RestrictionsAt the time of archiving, the student author of this thesis opted to temporarily restrict access to it. The full text of this thesis became available to the public after the expiration of the embargo on 2019-08-11.
AbstractPincer complexes moieties have attracted much attention in the past years. They have been proved that they are highly active catalysts in many different known transition metal-catalyzed organic reaction and some unpredictable organic transformation. In this thesis, we will use PN3P Cobalt pincer complex in two different applications. The first application is the unpresented Cobalt-catalyzed hydrogenation of nitriles to secondary imines. The selective hydrogenation of nitriles into secondary imines is a very challenging task and the catalysts play a very important role in the reaction and the selectivity. Herein in the thesis, we report the first selective hydrogenation of nitriles to secondary imines catalyzed by a well-defined and accessible PN3P cobalt pincer complex. Our results show different selectivity compared with the known PNP cobalt catalytic system during the nitriles hydrogenation. A set of aliphatic and aromatic nitriles are hydrogenated to the secondary imine under relatively mild conditions. The second application is the alkylation of nitriles with alcohols using PN3P cobalt pincer complex. The alcohol is being used here as alkylating agent in state of using toxic alkyl halides or excess amount of base to avoid any salt waste. The cobalt pincer complex work as catalyst for transformation that undergoes alkylation via hydrogen transfer pathways. The beauty of this reaction that it is delver water as the only byproduct. A different nitriles and alcohol are tolerated in this reaction.
CitationAl Dakhil, A. (2018). Synthesis and Application of PN3P Cobalt Pincer Complex for Selective Hydrogenation of Nitriles to Secondary Imines and α -Alkylation of Nitriles with Alcohols. KAUST Research Repository. https://doi.org/10.25781/KAUST-T257F