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dc.contributor.authorAbulfaraj, Aala A.
dc.contributor.authorMariappan, Kiruthiga
dc.contributor.authorBigeard, Jean
dc.contributor.authorManickam, Prabhu
dc.contributor.authorBlilou, Ikram
dc.contributor.authorGuo, Xiujie
dc.contributor.authorAl-Babili, Salim
dc.contributor.authorPflieger, Delphine
dc.contributor.authorHirt, Heribert
dc.contributor.authorRayapuram, Naganand
dc.date.accessioned2018-06-03T08:15:54Z
dc.date.available2018-06-03T08:15:54Z
dc.date.issued2018-05-31
dc.identifier.citationAbulfaraj AA, Mariappan K, Bigeard J, Manickam P, Blilou I, et al. (2018) TheArabidopsishomolog of human G3BP1 is a key regulator of stomatal and apoplastic immunity. Life Science Alliance 1: e201800046. Available: http://dx.doi.org/10.26508/lsa.201800046.
dc.identifier.issn2575-1077
dc.identifier.doi10.26508/lsa.201800046
dc.identifier.urihttp://hdl.handle.net/10754/628011
dc.description.abstractMammalian Ras-GTPase–activating protein SH3-domain–binding proteins (G3BPs) are a highly conserved family of RNA-binding proteins that link kinase receptor-mediated signaling to RNA metabolism. Mammalian G3BP1 is a multifunctional protein that functions in viral immunity. Here, we show that the Arabidopsis thaliana homolog of human G3BP1 negatively regulates plant immunity. Arabidopsis g3bp1 mutants showed enhanced resistance to the virulent bacterial pathogen Pseudomonas syringae pv. tomato. Pathogen resistance was mediated in Atg3bp1 mutants by altered stomatal and apoplastic immunity. Atg3bp1 mutants restricted pathogen entry into stomates showing insensitivity to bacterial coronatine–mediated stomatal reopening. AtG3BP1 was identified as a negative regulator of defense responses, which correlated with moderate up-regulation of salicylic acid biosynthesis and signaling without growth penalty.
dc.description.sponsorshipThis work was supported by the King Abdullah University of Science and Technology and Agence Nationale de la Recherche (ANR-2010-JCJC-1608). The Institute of Plant Sciences Paris-Saclay benefits from the support of the LabEx Saclay Plant Sciences (ANR-10-LABX-0040-SPS).
dc.publisherLife Science Alliance, LLC
dc.relation.urlhttp://www.life-science-alliance.org/content/1/2/e201800046
dc.rightsArchived with thanks to Life Science Alliance
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectPlant Science
dc.subjectMicrobiology, Virology & Host Pathogen Interaction
dc.titleThe Arabidopsis homolog of human G3BP1 is a key regulator of stomatal and apoplastic immunity
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentDesert Agriculture Initiative
dc.contributor.departmentPlant Science
dc.contributor.departmentRed Sea Research Center (RSRC)
dc.identifier.journalLife Science Alliance
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionDepartment of Biology, Science and Arts College, Rabigh Campus, King Abdulaziz University, Jeddah, Saudi Arabia
dc.contributor.institutionInstitute of Plant Sciences Paris-Saclay, Paris Diderot, Sorbonne Paris-Cite, Orsay, France
dc.contributor.institutionInstitute of Plant Sciences Paris-Saclay, CNRS, INRA, Universite Paris-Sud, Universite Evry, Universite Paris-Saclay, Orsay, France
dc.contributor.institutionCNRS, BIG-BGE FR3425, Grenoble, France
dc.contributor.institutionUniversite Grenoble Alpes, CEA, Inserm, BIG-BGE, Grenoble, France
kaust.personAbulfaraj, Aala Abdulaziz Hussien
kaust.personMariappan, Kiruthiga
kaust.personManickam, Prabhu
kaust.personBlilou, Ikram
kaust.personGuo, Xiujie
kaust.personAl-Babili, Salim
kaust.personHirt, Heribert
kaust.personRayapuram, Naganand
refterms.dateFOA2018-06-14T08:24:01Z
dc.date.published-online2018-05-31
dc.date.published-print2018-05


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