The Arabidopsis homolog of human G3BP1 is a key regulator of stomatal and apoplastic immunity
AuthorsAbulfaraj, Aala A.
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Red Sea Research Center (RSRC)
Desert Agriculture Initiative
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AbstractMammalian Ras-GTPase–activating protein SH3-domain–binding proteins (G3BPs) are a highly conserved family of RNA-binding proteins that link kinase receptor-mediated signaling to RNA metabolism. Mammalian G3BP1 is a multifunctional protein that functions in viral immunity. Here, we show that the Arabidopsis thaliana homolog of human G3BP1 negatively regulates plant immunity. Arabidopsis g3bp1 mutants showed enhanced resistance to the virulent bacterial pathogen Pseudomonas syringae pv. tomato. Pathogen resistance was mediated in Atg3bp1 mutants by altered stomatal and apoplastic immunity. Atg3bp1 mutants restricted pathogen entry into stomates showing insensitivity to bacterial coronatine–mediated stomatal reopening. AtG3BP1 was identified as a negative regulator of defense responses, which correlated with moderate up-regulation of salicylic acid biosynthesis and signaling without growth penalty.
CitationAbulfaraj AA, Mariappan K, Bigeard J, Manickam P, Blilou I, et al. (2018) TheArabidopsishomolog of human G3BP1 is a key regulator of stomatal and apoplastic immunity. Life Science Alliance 1: e201800046. Available: http://dx.doi.org/10.26508/lsa.201800046.
SponsorsThis work was supported by the King Abdullah University of Science and Technology and Agence Nationale de la Recherche (ANR-2010-JCJC-1608). The Institute of Plant Sciences Paris-Saclay benefits from the support of the LabEx Saclay Plant Sciences (ANR-10-LABX-0040-SPS).
PublisherLife Science Alliance, LLC
JournalLife Science Alliance
Except where otherwise noted, this item's license is described as Archived with thanks to Life Science Alliance