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    Nanoscopical dissection of ancestral nucleoli in Archaea: a case of study in Evolutionary Cell Biology

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    Name:
    PARSIFAL ISLAS MORALES MASTER THESIS_Final.pdf
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    37.44Mb
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    PDF
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    PARSIFAL ISLAS MORALES MASTER THESIS_Final
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    Type
    Thesis
    Authors
    Islas Morales, Parsifal cc
    Advisors
    Voolstra, Christian R. cc
    Committee members
    García, Luis Felipe Jimenez
    Aranda, Manuel cc
    Gojobori, Takashi cc
    Program
    Marine Science
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Date
    2018-04
    Embargo End Date
    2019-05-17
    Permanent link to this record
    http://hdl.handle.net/10754/627920
    
    Metadata
    Show full item record
    Access Restrictions
    At the time of archiving, the student author of this thesis opted to temporarily restrict access to it. The full text of this thesis became available to the public after the expiration of the embargo on 2019-05-17.
    Abstract
    Is the nucleolus a sine qua non condition of eukaryotes? The present project starts from this central question to contribute to our knowledge about the origin and the evolution of the cells. The nucleolus is a cryptic organelle that plays a central role in cell function. It is responsible for the orchestration of ribosomal RNA expression, maturation and modification in the regulatory context of cellular homeostasis. Ribosomal expression is undoubtedly the greatest transcriptional and regulatory activity of any cell. The nucleolus is not just a conventional organelle –membrane-limited-, but a magnificent transcriptional puff: a dichotomy between structure and process, form and function. What is the minimum nucleolus? Evolution should bring some light into these questions. Evolutionary cell biology (ECB) has raised increasing attention in the last decades. Is this a new discipline and an historical opportunity to combine functional and evolutionary biology towards the insight that cell evolution underlies organismic complexity? In the post-genomic era, we have developed the potential of combining high throughput acquisition of data with functional in situ and in sillico approaches: integration understood as omics approaches. Can this provide a real consilience between evolutionary and functional approaches? The reduced number of model organisms and cultivation techniques still excludes the majority of the extant diversity of cells from the scope of experimental inquiry. Furthermore, at the conceptual level, the simplification of evolutionary processes in biosciences still limits the conformation of a successful disciplinary link between functional and evolutionary biology. This limits the formulation of questions and experiments that properly address the mechanistic nature of cellular events that underlie microbial and organismic diversity and evolution. Here we provide a critical and comparative review to the historical background of ECB. This project takes the lessons learned from ECB and attempts to find a homologue structure of the eukaryotic nucleolus within the Archaea. We found nanometric structures in S. solfactarius that either are positive to specific nucleolar techniques such as Nucleolar organizer regions NOR silver staining. These is structures are novel and its significance should be revised on the evolutionary cell biology perspective.
    Citation
    Islas Morales, P. (2018). Nanoscopical dissection of ancestral nucleoli in Archaea: a case of study in Evolutionary Cell Biology. KAUST Research Repository. https://doi.org/10.25781/KAUST-6Y110
    DOI
    10.25781/KAUST-6Y110
    ae974a485f413a2113503eed53cd6c53
    10.25781/KAUST-6Y110
    Scopus Count
    Collections
    Biological and Environmental Sciences and Engineering (BESE) Division; Marine Science Program; Theses; Theses

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