Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development
Type
ArticleKAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Computational Bioscience Research Center (CBRC)
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
KAUST Grant Number
URF/1/2602-01-01Date
2018-06-11Permanent link to this record
http://hdl.handle.net/10754/627898
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Show full item recordAbstract
Focal adhesion kinase (FAK) and its close paralogue, proline-rich tyrosine kinase 2 (PYK2), are key regulators of aggressive spreading and metastasis of cancer cells. While targeted small-molecule inhibitors of FAK and PYK2 have been found to have promising antitumor activity, their clinical long-term efficacy may be undermined by the strong capacity of cancer cells to evade anti-kinase drugs. In healthy cells, the expression and/or function of FAK and PYK2 is tightly controlled via modulation of gene expression, competing alternatively spliced forms, non-coding RNAs, and proteins that directly or indirectly affect kinase activation or protein stability. The molecular factors involved in this control are frequently deregulated in cancer cells. Here, we review the endogenous mechanisms controlling FAK and PYK2, and with particular focus on how these mechanisms could inspire or improve anticancer therapies.Citation
Naser R, Aldehaiman A, Díaz-Galicia E, Arold S (2018) Endogenous Control Mechanisms of FAK and PYK2 and Their Relevance to Cancer Development. Cancers 10: 196. Available: http://dx.doi.org/10.3390/cancers10060196.Sponsors
This publication was supported by King Abdullah University of Science and Technology (KAUST) through baseline funds and Award No. URF/1/2602-01-01 from the Office of Sponsored Research (OSR). We thank Virginia Unkefer for editorial assistance and Jean-Antoine Girault, Seungbeom Hong, Bilal M. Qureshi and Afaque-Ahmad Momin for suggestions and discussions. We apologize to all colleagues whose research could not be discussed because of space constraints.Publisher
MDPI AGJournal
CancersAdditional Links
http://www.mdpi.com/2072-6694/10/6/196ae974a485f413a2113503eed53cd6c53
10.3390/cancers10060196
Scopus Count
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