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Cross-Coupling of Amides with Alkylboranes via Nickel-Catalyzed C–N Bond Cleavage

dc.contributor.authorLiu, Xiangqian
dc.contributor.authorHsiao, Chien-Chi
dc.contributor.authorGuo, Lin
dc.contributor.authorRueping, Magnus
dc.date.accessioned2018-05-15T05:25:52Z
dc.date.available2018-05-15T05:25:52Z
dc.date.issued2018-05-09
dc.identifier.citationLiu X, Hsiao C-C, Guo L, Rueping M (2018) Cross-Coupling of Amides with Alkylboranes via Nickel-Catalyzed C–N Bond Cleavage. Organic Letters. Available: http://dx.doi.org/10.1021/acs.orglett.8b01021.
dc.identifier.issn1523-7060
dc.identifier.issn1523-7052
dc.identifier.doi10.1021/acs.orglett.8b01021
dc.identifier.urihttp://hdl.handle.net/10754/627875
dc.description.abstractA protocol for the nickel-catalyzed alkylation of amides was established. The use of alkylboranes as nucleophilic partners allowed the use of mild reaction conditions and compatibility of various functional groups with respect to both coupling partners. The catalytic alkylation proceeded selectively at the amides in the presence of other functional groups as well as other carboxylic acid derived moieties.
dc.description.sponsorshipX.L. and L.G. gratefully acknowledge financial support from the China Scholarship Council. This research was supported by King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research under Award No. URF/1/3030-01.
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttps://pubs.acs.org/doi/full/10.1021/acs.orglett.8b01021
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://pubs.acs.org/doi/full/10.1021/acs.orglett.8b01021.
dc.titleCross-Coupling of Amides with Alkylboranes via Nickel-Catalyzed C–N Bond Cleavage
dc.typeArticle
dc.contributor.departmentChemical Science Program
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalOrganic Letters
dc.eprint.versionPost-print
dc.contributor.institutionRWTH Aachen University, Institute of Organic Chemistry, Landoltweg 1, 52074 Aachen, Germany
kaust.personRueping, Magnus
kaust.grant.numberURF/1/3030-01
dc.date.published-online2018-05-09
dc.date.published-print2018-05-18


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