Impact of MCT1 Haploinsufficiency on the Mouse Retina
Type
Book ChapterAuthors
Peachey, Neal S.Yu, Minzhong
Han, John Y. S.
Lengacher, Sylvain
Magistretti, Pierre J.
Pellerin, Luc
Philp, Nancy J.
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Date
2018-05-02Online Publication Date
2018-05-03Print Publication Date
2018Permanent link to this record
http://hdl.handle.net/10754/627851Metadata
Show full item recordAbstract
The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1+/− heterozygotes, which express half of the normal complement of MCT1. The MCT1+/− retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.Citation
Peachey NS, Yu M, Han JYS, Lengacher S, Magistretti PJ, et al. (2018) Impact of MCT1 Haploinsufficiency on the Mouse Retina. Advances in Experimental Medicine and Biology: 375–380. Available: http://dx.doi.org/10.1007/978-3-319-75402-4_46.Sponsors
This work was supported by grants from NIH (R01EY12042) and Department of Veterans Affairs (I01BX2340) and by the Foundation Fighting Blindness and Research to Prevent Blindness.Publisher
Springer NatureAdditional Links
http://link.springer.com/chapter/10.1007/978-3-319-75402-4_46http://europepmc.org/articles/pmc6708593?pdf=render