Impact of MCT1 Haploinsufficiency on the Mouse Retina

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Type
Book Chapter
Authors
Peachey, Neal S.
Yu, Minzhong
Han, John Y. S.
Lengacher, Sylvain
Magistretti, Pierre J. cc
Pellerin, Luc
Philp, Nancy J.
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) Division
Bioscience Program
Date
2018-05-02
Online Publication Date
2018-05-03
Print Publication Date
2018
Embargo End Date
2019-05-02
Permanent link to this record
http://hdl.handle.net/10754/627851

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Abstract
The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1+/− heterozygotes, which express half of the normal complement of MCT1. The MCT1+/− retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.
Citation
Peachey NS, Yu M, Han JYS, Lengacher S, Magistretti PJ, et al. (2018) Impact of MCT1 Haploinsufficiency on the Mouse Retina. Advances in Experimental Medicine and Biology: 375–380. Available: http://dx.doi.org/10.1007/978-3-319-75402-4_46.
Sponsors
This work was supported by grants from NIH (R01EY12042) and Department of Veterans Affairs (I01BX2340) and by the Foundation Fighting Blindness and Research to Prevent Blindness.
Publisher
Springer International Publishing
Journal
Advances in Experimental Medicine and Biology
DOI
10.1007/978-3-319-75402-4_46
Additional Links
http://link.springer.com/chapter/10.1007/978-3-319-75402-4_46
http://europepmc.org/articles/pmc6708593?pdf=render
Collections
Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; Book Chapters