AuthorsPeachey, Neal S.
Han, John Y. S.
Magistretti, Pierre J.
Philp, Nancy J.
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
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AbstractThe monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1+/− heterozygotes, which express half of the normal complement of MCT1. The MCT1+/− retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.
CitationPeachey NS, Yu M, Han JYS, Lengacher S, Magistretti PJ, et al. (2018) Impact of MCT1 Haploinsufficiency on the Mouse Retina. Advances in Experimental Medicine and Biology: 375–380. Available: http://dx.doi.org/10.1007/978-3-319-75402-4_46.
SponsorsThis work was supported by grants from NIH (R01EY12042) and Department of Veterans Affairs (I01BX2340) and by the Foundation Fighting Blindness and Research to Prevent Blindness.
PublisherSpringer International Publishing