Iridium-Catalyzed Regioselective Borylation of Substituted Biaryls
Emwas, Abdul-Hamid M.
KAUST DepartmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Computer Science Program
Computational Bioscience Research Center (CBRC)
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AbstractBiarylboronic esters are generally prepared by directed ortho -metalation or by Miyaura borylation and hence rely on the presence of a directing group or pre-functionalization. In this paper, the preparation of biarylboronic esters by direct C–H borylation of biaryl substrates is reported. Sterically governed regioselectivities were observed in the borylation of appropriately substituted biaryls by using [Ir(OMe)(COD)] precatalyst and di- tert -butylbipyridyl ligand. The resulting biarylboronic esters were isolated in 38–98% yields. The synthesized biarylboronic esters were further successfully employed in C–O, C–Br, and C–C coupling reactions.
CitationChotana G, Asghar S, Shahzadi T, Alazmi M, Gao X, et al. (2018) Iridium-Catalyzed Regioselective Borylation of Substituted Biaryls. Synthesis. Available: http://dx.doi.org/10.1055/s-0036-1591968.
SponsorsWe extend our acknowledgement to KAUST core labs facilities, and the University of Bristol, UK, for NMR and HRMS measurements.
PublisherGeorg Thieme Verlag KG