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dc.contributor.authorLi, Mo
dc.contributor.authorBelmonte, Juan Carlos Izpisua
dc.date.accessioned2018-04-24T07:48:28Z
dc.date.available2018-04-24T07:48:28Z
dc.date.issued2018-03-28
dc.identifier.citationLi M, Izpisua Belmonte JC (2018) Deconstructing the pluripotency gene regulatory network. Nature Cell Biology 20: 382–392. Available: http://dx.doi.org/10.1038/s41556-018-0067-6.
dc.identifier.issn1465-7392
dc.identifier.issn1476-4679
dc.identifier.pmid29593328
dc.identifier.doi10.1038/s41556-018-0067-6
dc.identifier.urihttp://hdl.handle.net/10754/627625
dc.description.abstractPluripotent stem cells can be isolated from embryos or derived by reprogramming. Pluripotency is stabilized by an interconnected network of pluripotency genes that cooperatively regulate gene expression. Here we describe the molecular principles of pluripotency gene function and highlight post-transcriptional controls, particularly those induced by RNA-binding proteins and alternative splicing, as an important regulatory layer of pluripotency. We also discuss heterogeneity in pluripotency regulation, alternative pluripotency states and future directions of pluripotent stem cell research.
dc.description.sponsorshipWe apologize to the colleagues whose works are not covered due to space constraint. We would like to thank May Schwarz, Peter Schwarz, Chunmei Xia and Xingxing Zhang for generous administrative help during the preparation of the manuscript. We would like to thank the anonymous reviewers whose input has resulted in an improved manuscript. Work in the laboratory of M.L. was supported by King Abdullah University of Science and Technology (KAUST). Work in the laboratory of J.C.I.B. was supported by the G. Harold and Leila Y. Mathers Charitable Foundation, The Leona M. and Harry B. Helmsley Charitable Trust (2012-PG-MED002), the Moxie Foundation, NIH (5 DP1 DK113616 and R21AG055938), Progeria Research Foundation, Fundacion Dr. Pedro Guillen and the Universidad Católica San Antonio de Murcia (UCAM).
dc.publisherSpringer Science and Business Media LLC
dc.relation.urlhttps://www.nature.com/articles/s41556-018-0067-6
dc.relation.urlhttp://europepmc.org/articles/pmc6620196?pdf=render
dc.rightsThe final publication is available at Springer via http://dx.doi.org/10.1038/s41556-018-0067-6
dc.rightsThis file is an open access version redistributed from: http://europepmc.org/articles/pmc6620196?pdf=render
dc.titleDeconstructing the pluripotency gene regulatory network
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalNature Cell Biology
dc.rights.embargodate2018-09-28
dc.eprint.versionPost-print
dc.contributor.institutionSalk Institute for Biological Studies, San Digo, CA, , United States
kaust.personLi, Mo
refterms.dateFOA2021-06-23T06:18:18Z
dc.date.published-online2018-03-28
dc.date.published-print2018-04


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