KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
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AbstractPluripotent stem cells can be isolated from embryos or derived by reprogramming. Pluripotency is stabilized by an interconnected network of pluripotency genes that cooperatively regulate gene expression. Here we describe the molecular principles of pluripotency gene function and highlight post-transcriptional controls, particularly those induced by RNA-binding proteins and alternative splicing, as an important regulatory layer of pluripotency. We also discuss heterogeneity in pluripotency regulation, alternative pluripotency states and future directions of pluripotent stem cell research.
CitationLi M, Izpisua Belmonte JC (2018) Deconstructing the pluripotency gene regulatory network. Nature Cell Biology 20: 382–392. Available: http://dx.doi.org/10.1038/s41556-018-0067-6.
SponsorsWe apologize to the colleagues whose works are not covered due to space constraint. We would like to thank May Schwarz, Peter Schwarz, Chunmei Xia and Xingxing Zhang for generous administrative help during the preparation of the manuscript. We would like to thank the anonymous reviewers whose input has resulted in an improved manuscript. Work in the laboratory of M.L. was supported by King Abdullah University of Science and Technology (KAUST). Work in the laboratory of J.C.I.B. was supported by the G. Harold and Leila Y. Mathers Charitable Foundation, The Leona M. and Harry B. Helmsley Charitable Trust (2012-PG-MED002), the Moxie Foundation, NIH (5 DP1 DK113616 and R21AG055938), Progeria Research Foundation, Fundacion Dr. Pedro Guillen and the Universidad Católica San Antonio de Murcia (UCAM).
JournalNature Cell Biology
- Ground rules of the pluripotency gene regulatory network.
- Authors: Li M, Belmonte JC
- Issue date: 2017 Mar
- Mechanisms of gene regulation in human embryos and pluripotent stem cells.
- Authors: Theunissen TW, Jaenisch R
- Issue date: 2017 Dec 15
- Pluripotency, Differentiation, and Reprogramming: A Gene Expression Dynamics Model with Epigenetic Feedback Regulation.
- Authors: Miyamoto T, Furusawa C, Kaneko K
- Issue date: 2015 Aug
- MBNL proteins repress ES-cell-specific alternative splicing and reprogramming.
- Authors: Han H, Irimia M, Ross PJ, Sung HK, Alipanahi B, David L, Golipour A, Gabut M, Michael IP, Nachman EN, Wang E, Trcka D, Thompson T, O'Hanlon D, Slobodeniuc V, Barbosa-Morais NL, Burge CB, Moffat J, Frey BJ, Nagy A, Ellis J, Wrana JL, Blencowe BJ
- Issue date: 2013 Jun 13
- Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming.
- Authors: Hirsch CL, Coban Akdemir Z, Wang L, Jayakumaran G, Trcka D, Weiss A, Hernandez JJ, Pan Q, Han H, Xu X, Xia Z, Salinger AP, Wilson M, Vizeacoumar F, Datti A, Li W, Cooney AJ, Barton MC, Blencowe BJ, Wrana JL, Dent SY
- Issue date: 2015 Apr 15