CRISPR/Cas13 as a Tool for RNA Interference

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Type
Article
Authors
Ali, Zahir cc
Mahas, Ahmed
Mahfouz, Magdy M. cc
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) Division
Bioscience Program
Desert Agriculture Initiative
Laboratory for Genome Engineering
KAUST Grant Number
OSR-2015-CRG4-2647
Date
2018-03-28

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Abstract
Almost all biological processes involve RNA, making it crucial to develop tools for manipulation of the transcriptome. The bacterial CRISPR/Cas13 system was recently rewired to facilitate RNA manipulation in eukaryotes, including plants. We discuss here the opportunities and limitations of using CRISPR/Cas13 in plants for various types of RNA manipulation.
Citation
Ali Z, Mahas A, Mahfouz M (2018) CRISPR/Cas13 as a Tool for RNA Interference. Trends in Plant Science 23: 374–378. Available: http://dx.doi.org/10.1016/j.tplants.2018.03.003.
Sponsors
We wish to thank the Office of Sponsored Research (OSR) and King Abdullah University of Science and Technology (KAUST) for their support (award OSR-2015-CRG4-2647).
Publisher
Elsevier BV
Journal
Trends in Plant Science
ISSN
1360-1385
DOI
10.1016/j.tplants.2018.03.003
PubMed ID
29605099
Handle URI
http://hdl.handle.net/10754/627624
Additional Links
http://www.sciencedirect.com/science/article/pii/S1360138518300451
Collections
Articles; Bioscience Program; Desert Agriculture Initiative; Biological and Environmental Sciences and Engineering (BESE) Division