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    Nail lesions in 30 old inbred mouse strains

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    Type
    Poster
    Presentation
    Authors
    Linn, S.C.
    Mustonen, A.M.
    Silva, K.A.
    Kennedy, V.E.
    Sundberg, B.A.
    Bechtold, L.S.
    Cusolito, L.R.
    Alghamdi, S.
    Hoehndorf, Robert cc
    Schofield, P.N.
    Sundberg, J.P.
    KAUST Department
    Bio-Ontology Research Group (BORG)
    Computational Bioscience Research Center (CBRC)
    Computer Science Program
    Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
    Date
    2018-04-19
    Online Publication Date
    2018-04-19
    Print Publication Date
    2018-05
    Permanent link to this record
    http://hdl.handle.net/10754/627593
    
    Metadata
    Show full item record
    Abstract
    In a large scale aging study, 30 inbred strains were necropsied at 12, 20, and greater than 20 months of age. Ten strains were identified with nail lesions; the highest frequency was noted in NON/ShiLtJ mice. To determine if these lesions occurred in younger mice, NON/ShiLtJ mice, 57-241 days of age, were obtained. Lesions identified fell into two main categories: acute to chronic penetration of the third phalangeal bone through the hyponychium with associated inflammation and bone remodeling or metaplasia of the nail matrix and nail bed associated with severe orthokeratotic hyperkeratosis replacing the nail plate. Penetration of the distal phalanx through the hyponychium appeared to be the initiating feature. The acute to subacute inflammatory response was associated with osteolysis of the distal phalanx. The highest frequency of nail lesions was in the NON/ShiLtJ and NZW/Lac1J strains with a strong female predilection. Younger NON/ShiLtJ mice revealed that these lesions were infrequent or affected only one digit. The only other nail unit abnormality identified was sporadic subungual intraosseous epidermoid inclusion cysts that closely resembled similar lesions reported in humans, dogs, and horses.
    Citation
    Linn SC, Mustonen AM, Silva KA, Kennedy VE, Sundberg BA, et al. (2018) 665 Nail lesions in 30 old inbred mouse strains. Journal of Investigative Dermatology 138: S113. Available: http://dx.doi.org/10.1016/j.jid.2018.03.674.
    Publisher
    Elsevier BV
    Journal
    Journal of Investigative Dermatology
    Conference/Event name
    International Investigative Dermatology (IID) 2018
    DOI
    10.1016/j.jid.2018.03.674
    Additional Links
    http://www.sciencedirect.com/science/article/pii/S0022202X1830900X
    http://iid2018.org/
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jid.2018.03.674
    Scopus Count
    Collections
    Bio-Ontology Research Group (BORG); Posters; Computer Science Program; Computational Bioscience Research Center (CBRC); Computer, Electrical and Mathematical Science and Engineering (CEMSE) Division

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