Rhenium and Manganese-Catalyzed Selective Alkenylation of Indoles
KAUST DepartmentPhysical Sciences and Engineering (PSE) Division
Chemical Science Program
KAUST Catalysis Center (KCC)
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AbstractAn efficient rhenium‐catalyzed regioselective C‐H bond alkenylation of indoles is reported. The protocol operates well for internal as well as terminal alkynes, affording products in good to excellent yields. Furthermore, a manganese catalyzed, acid free, regioselective C2‐alkenylation of indoles with internal alkynes is described. The directing groups can be easily removed after the reaction and the resulting products can be used as valuable building blocks for the synthesis of diverse heterocyclic compounds.
CitationWang C, Rueping M (2018) Rhenium and Manganese-Catalyzed Selective Alkenylation of Indoles. ChemCatChem. Available: http://dx.doi.org/10.1002/cctc.201800553.