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dc.contributor.authorMagistretti, Pierre J.
dc.contributor.authorAllaman, Igor
dc.date.accessioned2018-04-15T07:13:35Z
dc.date.available2018-04-15T07:13:35Z
dc.date.issued2018-03-08
dc.identifier.citationMagistretti PJ, Allaman I (2018) Lactate in the brain: from metabolic end-product to signalling molecule. Nature Reviews Neuroscience 19: 235–249. Available: http://dx.doi.org/10.1038/nrn.2018.19.
dc.identifier.issn1471-003X
dc.identifier.issn1471-0048
dc.identifier.pmid29515192
dc.identifier.doi10.1038/nrn.2018.19
dc.identifier.urihttp://hdl.handle.net/10754/627454
dc.description.abstractLactate in the brain has long been associated with ischaemia; however, more recent evidence shows that it can be found there under physiological conditions. In the brain, lactate is formed predominantly in astrocytes from glucose or glycogen in response to neuronal activity signals. Thus, neurons and astrocytes show tight metabolic coupling. Lactate is transferred from astrocytes to neurons to match the neuronal energetic needs, and to provide signals that modulate neuronal functions, including excitability, plasticity and memory consolidation. In addition, lactate affects several homeostatic functions. Overall, lactate ensures adequate energy supply, modulates neuronal excitability levels and regulates adaptive functions in order to set the 'homeostatic tone' of the nervous system.
dc.description.sponsorshipResearch in P.J.M.'s laboratory has been supported over the years by the Swiss National Science Foundation, King Abdullah University of Science and Technology (KAUST; Saudi Arabia), the University of Lausanne (UNIL; Switzerland), École Polytechnique Fédérale de Lausanne (EPFL; Switzerland), Centre Hospitalier Universitaire Vaudois (CHUV; Switzerland), the National Centre for Competence in Research (NCCR) Synapsy and the Préfargier Foundation. The authors thank H. Fiumelli and F. Barros for comments on the manuscript.
dc.publisherSpringer Nature
dc.relation.urlhttps://www.nature.com/articles/nrn.2018.19
dc.titleLactate in the brain: from metabolic end-product to signalling molecule
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalNature Reviews Neuroscience
dc.contributor.institutionBrain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
kaust.personMagistretti, Pierre J.
dc.date.published-online2018-03-08
dc.date.published-print2018-04


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