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    Lactate in the brain: from metabolic end-product to signalling molecule

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    Type
    Article
    Authors
    Magistretti, Pierre J. cc
    Allaman, Igor
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Date
    2018-03-08
    Online Publication Date
    2018-03-08
    Print Publication Date
    2018-04
    Permanent link to this record
    http://hdl.handle.net/10754/627454
    
    Metadata
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    Abstract
    Lactate in the brain has long been associated with ischaemia; however, more recent evidence shows that it can be found there under physiological conditions. In the brain, lactate is formed predominantly in astrocytes from glucose or glycogen in response to neuronal activity signals. Thus, neurons and astrocytes show tight metabolic coupling. Lactate is transferred from astrocytes to neurons to match the neuronal energetic needs, and to provide signals that modulate neuronal functions, including excitability, plasticity and memory consolidation. In addition, lactate affects several homeostatic functions. Overall, lactate ensures adequate energy supply, modulates neuronal excitability levels and regulates adaptive functions in order to set the 'homeostatic tone' of the nervous system.
    Citation
    Magistretti PJ, Allaman I (2018) Lactate in the brain: from metabolic end-product to signalling molecule. Nature Reviews Neuroscience 19: 235–249. Available: http://dx.doi.org/10.1038/nrn.2018.19.
    Sponsors
    Research in P.J.M.'s laboratory has been supported over the years by the Swiss National Science Foundation, King Abdullah University of Science and Technology (KAUST; Saudi Arabia), the University of Lausanne (UNIL; Switzerland), École Polytechnique Fédérale de Lausanne (EPFL; Switzerland), Centre Hospitalier Universitaire Vaudois (CHUV; Switzerland), the National Centre for Competence in Research (NCCR) Synapsy and the Préfargier Foundation. The authors thank H. Fiumelli and F. Barros for comments on the manuscript.
    Publisher
    Springer Nature
    Journal
    Nature Reviews Neuroscience
    DOI
    10.1038/nrn.2018.19
    PubMed ID
    29515192
    Additional Links
    https://www.nature.com/articles/nrn.2018.19
    ae974a485f413a2113503eed53cd6c53
    10.1038/nrn.2018.19
    Scopus Count
    Collections
    Articles; Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program

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