Lactate in the brain: from metabolic end-product to signalling molecule
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
King Abdullah University of Science and Technology (KAUST), Thuwal, Kingdom of Saudi Arabia.
MetadataShow full item record
AbstractLactate in the brain has long been associated with ischaemia; however, more recent evidence shows that it can be found there under physiological conditions. In the brain, lactate is formed predominantly in astrocytes from glucose or glycogen in response to neuronal activity signals. Thus, neurons and astrocytes show tight metabolic coupling. Lactate is transferred from astrocytes to neurons to match the neuronal energetic needs, and to provide signals that modulate neuronal functions, including excitability, plasticity and memory consolidation. In addition, lactate affects several homeostatic functions. Overall, lactate ensures adequate energy supply, modulates neuronal excitability levels and regulates adaptive functions in order to set the 'homeostatic tone' of the nervous system.
CitationMagistretti PJ, Allaman I (2018) Lactate in the brain: from metabolic end-product to signalling molecule. Nature Reviews Neuroscience 19: 235–249. Available: http://dx.doi.org/10.1038/nrn.2018.19.
SponsorsResearch in P.J.M.'s laboratory has been supported over the years by the Swiss National Science Foundation, King Abdullah University of Science and Technology (KAUST; Saudi Arabia), the University of Lausanne (UNIL; Switzerland), École Polytechnique Fédérale de Lausanne (EPFL; Switzerland), Centre Hospitalier Universitaire Vaudois (CHUV; Switzerland), the National Centre for Competence in Research (NCCR) Synapsy and the Préfargier Foundation. The authors thank H. Fiumelli and F. Barros for comments on the manuscript.
JournalNature Reviews Neuroscience
- Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging.
- Authors: Magistretti PJ, Pellerin L
- Issue date: 1999 Jul 29
- The metabolic trinity, glucose-glycogen-lactate, links astrocytes and neurons in brain energetics, signaling, memory, and gene expression.
- Authors: Dienel GA
- Issue date: 2017 Jan 10
- Glycogenolysis in astrocytes supports blood-borne glucose channeling not glycogen-derived lactate shuttling to neurons: evidence from mathematical modeling.
- Authors: DiNuzzo M, Mangia S, Maraviglia B, Giove F
- Issue date: 2010 Dec
- Energy Metabolism of the Brain, Including the Cooperation between Astrocytes and Neurons, Especially in the Context of Glycogen Metabolism.
- Authors: Falkowska A, Gutowska I, Goschorska M, Nowacki P, Chlubek D, Baranowska-Bosiacka I
- Issue date: 2015 Oct 29
- Lactate produced by glycogenolysis in astrocytes regulates memory processing.
- Authors: Newman LA, Korol DL, Gold PE
- Issue date: 2011