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dc.contributor.authorYang, Kuikun
dc.contributor.authorLiu, Yijing
dc.contributor.authorLiu, Yi
dc.contributor.authorZhang, Qian
dc.contributor.authorKong, Chuncai
dc.contributor.authorYi, Chenglin
dc.contributor.authorZhou, Zijian
dc.contributor.authorWang, Zhantong
dc.contributor.authorZhang, Guofeng
dc.contributor.authorZhang, Yang
dc.contributor.authorKhashab, Niveen M.
dc.contributor.authorChen, Xiaoyuan
dc.contributor.authorNie, Zhihong
dc.date.accessioned2018-04-15T07:13:34Z
dc.date.available2018-04-15T07:13:34Z
dc.date.issued2018-03-15
dc.identifier.citationYang K, Liu Y, Liu Y, Zhang Q, Kong C, et al. (2018) Cooperative Assembly of Magneto-Nanovesicles with Tunable Wall Thickness and Permeability for MRI-Guided Drug Delivery. Journal of the American Chemical Society 140: 4666–4677. Available: http://dx.doi.org/10.1021/jacs.8b00884.
dc.identifier.issn0002-7863
dc.identifier.issn1520-5126
dc.identifier.pmid29543442
dc.identifier.doi10.1021/jacs.8b00884
dc.identifier.urihttp://hdl.handle.net/10754/627445
dc.description.abstractThis article describes the fabrication of nanosized magneto-vesicles (MVs) comprising tunable layers of densely packed superparamagnetic iron oxide nanoparticles (SPIONs) in membranes via cooperative assembly of polymer-tethered SPIONs and free poly(styrene)- b-poly(acrylic acid) (PS- b-PAA). The membrane thickness of MVs could be well controlled from 9.8 to 93.2 nm by varying the weight ratio of PS- b-PAA to SPIONs. The increase in membrane thickness was accompanied by the transition from monolayer MVs, to double-layered MVs and to multilayered MVs (MuMVs). This can be attributed to the variation in the hydrophobic/hydrophilic balance of polymer-grafted SPIONs upon the insertion and binding of PS- b-PAA onto the surface of nanoparticles. Therapeutic agents can be efficiently encapsulated in the hollow cavity of MVs and the release of payload can be tuned by varying the membrane thickness of nanovesicles. Due to the high packing density of SPIONs, the MuMVs showed the highest magnetization and transverse relaxivity rate ( r2) in magnetic resonance imaging (MRI) among these MVs and individual SPIONs. Upon intravenous injection, doxorubicin-loaded MuMVs conjugated with RGD peptides could be effectively enriched at tumor sites due to synergetic effect of magnetic and active targeting. As a result, they exhibited drastically enhanced signal in MRI, improved tumor delivery efficiency of drugs as well as enhanced antitumor efficacy, compared with groups with only magnetic or active targeting strategy. The unique nanoplatform may find applications in effective disease control by delivering imaging and therapy to organs/tissues that are not readily accessible by conventional delivery vehicles.
dc.description.sponsorshipZ.N. gratefully acknowledges the financial support of the National Science Foundation (grants: DMR-1255377 and CHE-1505839). N.M.K. and Z.N. further acknowledge the support provided by King Abdullah University of Science and Technology CRG-2015 grant. The work was also supported by the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health as well as the National Natural Science Foundation of China (31771036) and the Basic Research Program of Shenzhen (JCYJ20160422091238319). We also acknowledge the support of the Maryland NanoCenter and its AIMLab.
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttps://pubs.acs.org/doi/10.1021/jacs.8b00884
dc.titleCooperative Assembly of Magneto-Nanovesicles with Tunable Wall Thickness and Permeability for MRI-Guided Drug Delivery
dc.typeArticle
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentChemical Science Program
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentSmart Hybrid Materials (SHMs) lab
dc.identifier.journalJournal of the American Chemical Society
dc.contributor.institutionDepartment of Chemistry and Biochemistry, University of Maryland College Park, Maryland 20742, United States
dc.contributor.institutionLaboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Maryland 20892, United States
dc.contributor.institutionLiu, Yijing
kaust.personZhang, Yang
kaust.personKhashab, Niveen M.
kaust.grant.numberCRG-2015
dc.date.published-online2018-03-15
dc.date.published-print2018-04-04


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