Cooperative Assembly of Magneto-Nanovesicles with Tunable Wall Thickness and Permeability for MRI-Guided Drug Delivery
Type
ArticleAuthors
Yang, KuikunLiu, Yijing
Liu, Yi

Zhang, Qian
Kong, Chuncai

Yi, Chenglin
Zhou, Zijian
Wang, Zhantong
Zhang, Guofeng
Zhang, Yang
Khashab, Niveen M.

Chen, Xiaoyuan
Nie, Zhihong

KAUST Department
Advanced Membranes and Porous Materials Research CenterBiological and Environmental Sciences and Engineering (BESE) Division
Bioscience Program
Chemical Science Program
Physical Science and Engineering (PSE) Division
Smart Hybrid Materials (SHMs) lab
KAUST Grant Number
CRG-2015Date
2018-03-15Online Publication Date
2018-03-15Print Publication Date
2018-04-04Permanent link to this record
http://hdl.handle.net/10754/627445
Metadata
Show full item recordAbstract
This article describes the fabrication of nanosized magneto-vesicles (MVs) comprising tunable layers of densely packed superparamagnetic iron oxide nanoparticles (SPIONs) in membranes via cooperative assembly of polymer-tethered SPIONs and free poly(styrene)- b-poly(acrylic acid) (PS- b-PAA). The membrane thickness of MVs could be well controlled from 9.8 to 93.2 nm by varying the weight ratio of PS- b-PAA to SPIONs. The increase in membrane thickness was accompanied by the transition from monolayer MVs, to double-layered MVs and to multilayered MVs (MuMVs). This can be attributed to the variation in the hydrophobic/hydrophilic balance of polymer-grafted SPIONs upon the insertion and binding of PS- b-PAA onto the surface of nanoparticles. Therapeutic agents can be efficiently encapsulated in the hollow cavity of MVs and the release of payload can be tuned by varying the membrane thickness of nanovesicles. Due to the high packing density of SPIONs, the MuMVs showed the highest magnetization and transverse relaxivity rate ( r2) in magnetic resonance imaging (MRI) among these MVs and individual SPIONs. Upon intravenous injection, doxorubicin-loaded MuMVs conjugated with RGD peptides could be effectively enriched at tumor sites due to synergetic effect of magnetic and active targeting. As a result, they exhibited drastically enhanced signal in MRI, improved tumor delivery efficiency of drugs as well as enhanced antitumor efficacy, compared with groups with only magnetic or active targeting strategy. The unique nanoplatform may find applications in effective disease control by delivering imaging and therapy to organs/tissues that are not readily accessible by conventional delivery vehicles.Citation
Yang K, Liu Y, Liu Y, Zhang Q, Kong C, et al. (2018) Cooperative Assembly of Magneto-Nanovesicles with Tunable Wall Thickness and Permeability for MRI-Guided Drug Delivery. Journal of the American Chemical Society 140: 4666–4677. Available: http://dx.doi.org/10.1021/jacs.8b00884.Sponsors
Z.N. gratefully acknowledges the financial support of the National Science Foundation (grants: DMR-1255377 and CHE-1505839). N.M.K. and Z.N. further acknowledge the support provided by King Abdullah University of Science and Technology CRG-2015 grant. The work was also supported by the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health as well as the National Natural Science Foundation of China (31771036) and the Basic Research Program of Shenzhen (JCYJ20160422091238319). We also acknowledge the support of the Maryland NanoCenter and its AIMLab.Publisher
American Chemical Society (ACS)PubMed ID
29543442Additional Links
https://pubs.acs.org/doi/10.1021/jacs.8b00884ae974a485f413a2113503eed53cd6c53
10.1021/jacs.8b00884
Scopus Count
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