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    Cooperative Assembly of Magneto-Nanovesicles with Tunable Wall Thickness and Permeability for MRI-Guided Drug Delivery

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    Type
    Article
    Authors
    Yang, Kuikun
    Liu, Yijing
    Liu, Yi cc
    Zhang, Qian
    Kong, Chuncai cc
    Yi, Chenglin
    Zhou, Zijian
    Wang, Zhantong
    Zhang, Guofeng
    Zhang, Yang
    Khashab, Niveen M. cc
    Chen, Xiaoyuan
    Nie, Zhihong cc
    KAUST Department
    Advanced Membranes and Porous Materials Research Center
    Biological and Environmental Sciences and Engineering (BESE) Division
    Bioscience Program
    Chemical Science Program
    Physical Science and Engineering (PSE) Division
    Smart Hybrid Materials (SHMs) lab
    KAUST Grant Number
    CRG-2015
    Date
    2018-03-15
    Online Publication Date
    2018-03-15
    Print Publication Date
    2018-04-04
    Permanent link to this record
    http://hdl.handle.net/10754/627445
    
    Metadata
    Show full item record
    Abstract
    This article describes the fabrication of nanosized magneto-vesicles (MVs) comprising tunable layers of densely packed superparamagnetic iron oxide nanoparticles (SPIONs) in membranes via cooperative assembly of polymer-tethered SPIONs and free poly(styrene)- b-poly(acrylic acid) (PS- b-PAA). The membrane thickness of MVs could be well controlled from 9.8 to 93.2 nm by varying the weight ratio of PS- b-PAA to SPIONs. The increase in membrane thickness was accompanied by the transition from monolayer MVs, to double-layered MVs and to multilayered MVs (MuMVs). This can be attributed to the variation in the hydrophobic/hydrophilic balance of polymer-grafted SPIONs upon the insertion and binding of PS- b-PAA onto the surface of nanoparticles. Therapeutic agents can be efficiently encapsulated in the hollow cavity of MVs and the release of payload can be tuned by varying the membrane thickness of nanovesicles. Due to the high packing density of SPIONs, the MuMVs showed the highest magnetization and transverse relaxivity rate ( r2) in magnetic resonance imaging (MRI) among these MVs and individual SPIONs. Upon intravenous injection, doxorubicin-loaded MuMVs conjugated with RGD peptides could be effectively enriched at tumor sites due to synergetic effect of magnetic and active targeting. As a result, they exhibited drastically enhanced signal in MRI, improved tumor delivery efficiency of drugs as well as enhanced antitumor efficacy, compared with groups with only magnetic or active targeting strategy. The unique nanoplatform may find applications in effective disease control by delivering imaging and therapy to organs/tissues that are not readily accessible by conventional delivery vehicles.
    Citation
    Yang K, Liu Y, Liu Y, Zhang Q, Kong C, et al. (2018) Cooperative Assembly of Magneto-Nanovesicles with Tunable Wall Thickness and Permeability for MRI-Guided Drug Delivery. Journal of the American Chemical Society 140: 4666–4677. Available: http://dx.doi.org/10.1021/jacs.8b00884.
    Sponsors
    Z.N. gratefully acknowledges the financial support of the National Science Foundation (grants: DMR-1255377 and CHE-1505839). N.M.K. and Z.N. further acknowledge the support provided by King Abdullah University of Science and Technology CRG-2015 grant. The work was also supported by the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health as well as the National Natural Science Foundation of China (31771036) and the Basic Research Program of Shenzhen (JCYJ20160422091238319). We also acknowledge the support of the Maryland NanoCenter and its AIMLab.
    Publisher
    American Chemical Society (ACS)
    Journal
    Journal of the American Chemical Society
    DOI
    10.1021/jacs.8b00884
    PubMed ID
    29543442
    Additional Links
    https://pubs.acs.org/doi/10.1021/jacs.8b00884
    ae974a485f413a2113503eed53cd6c53
    10.1021/jacs.8b00884
    Scopus Count
    Collections
    Articles; Biological and Environmental Sciences and Engineering (BESE) Division; Bioscience Program; Advanced Membranes and Porous Materials Research Center; Physical Science and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program

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