Cooperative Assembly of Magneto-Nanovesicles with Tunable Wall Thickness and Permeability for MRI-Guided Drug Delivery
Khashab, Niveen M.
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Physical Sciences and Engineering (PSE) Division
Chemical Science Program
Advanced Membranes and Porous Materials Research Center
Smart Hybrid Materials (SHMs) lab
KAUST Grant NumberCRG-2015
MetadataShow full item record
AbstractThis article describes the fabrication of nanosized magneto-vesicles (MVs) comprising tunable layers of densely packed superparamagnetic iron oxide nanoparticles (SPIONs) in membranes via cooperative assembly of polymer-tethered SPIONs and free poly(styrene)- b-poly(acrylic acid) (PS- b-PAA). The membrane thickness of MVs could be well controlled from 9.8 to 93.2 nm by varying the weight ratio of PS- b-PAA to SPIONs. The increase in membrane thickness was accompanied by the transition from monolayer MVs, to double-layered MVs and to multilayered MVs (MuMVs). This can be attributed to the variation in the hydrophobic/hydrophilic balance of polymer-grafted SPIONs upon the insertion and binding of PS- b-PAA onto the surface of nanoparticles. Therapeutic agents can be efficiently encapsulated in the hollow cavity of MVs and the release of payload can be tuned by varying the membrane thickness of nanovesicles. Due to the high packing density of SPIONs, the MuMVs showed the highest magnetization and transverse relaxivity rate ( r2) in magnetic resonance imaging (MRI) among these MVs and individual SPIONs. Upon intravenous injection, doxorubicin-loaded MuMVs conjugated with RGD peptides could be effectively enriched at tumor sites due to synergetic effect of magnetic and active targeting. As a result, they exhibited drastically enhanced signal in MRI, improved tumor delivery efficiency of drugs as well as enhanced antitumor efficacy, compared with groups with only magnetic or active targeting strategy. The unique nanoplatform may find applications in effective disease control by delivering imaging and therapy to organs/tissues that are not readily accessible by conventional delivery vehicles.
CitationYang K, Liu Y, Liu Y, Zhang Q, Kong C, et al. (2018) Cooperative Assembly of Magneto-Nanovesicles with Tunable Wall Thickness and Permeability for MRI-Guided Drug Delivery. Journal of the American Chemical Society 140: 4666–4677. Available: http://dx.doi.org/10.1021/jacs.8b00884.
SponsorsZ.N. gratefully acknowledges the financial support of the National Science Foundation (grants: DMR-1255377 and CHE-1505839). N.M.K. and Z.N. further acknowledge the support provided by King Abdullah University of Science and Technology CRG-2015 grant. The work was also supported by the Intramural Research Program of the National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health as well as the National Natural Science Foundation of China (31771036) and the Basic Research Program of Shenzhen (JCYJ20160422091238319). We also acknowledge the support of the Maryland NanoCenter and its AIMLab.
PublisherAmerican Chemical Society (ACS)
- Superparamagnetic iron oxide nanoparticles conjugated with folic acid for dual target-specific drug delivery and MRI in cancer theranostics.
- Authors: Huang Y, Mao K, Zhang B, Zhao Y
- Issue date: 2017 Jan 1
- Rationally Separating the Corona and Membrane Functions of Polymer Vesicles for Enhanced T₂ MRI and Drug Delivery.
- Authors: Qin J, Liu Q, Zhang J, Chen J, Chen S, Zhao Y, Du J
- Issue date: 2015 Jul 1
- Noninvasive Imaging of Liposomal Delivery of Superparamagnetic Iron Oxide Nanoparticles to Orthotopic Human Breast Tumor in Mice.
- Authors: Kato Y, Zhu W, Backer MV, Neoh CC, Hapuarachchige S, Sarkar SK, Backer JM, Artemov D
- Issue date: 2015 Nov
- Folate-targeted polymeric micelles loaded with ultrasmall superparamagnetic iron oxide: combined small size and high MRI sensitivity.
- Authors: Hong GB, Zhou JX, Yuan RX
- Issue date: 2012
- Functionalized polymersomes with outlayered polyelectrolyte gels for potential tumor-targeted delivery of multimodal therapies and MR imaging.
- Authors: Chiang WH, Huang WC, Chang CW, Shen MY, Shih ZF, Huang YF, Lin SC, Chiu HC
- Issue date: 2013 Jun 28