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dc.contributor.authorPerdigão, João
dc.contributor.authorSilva, Carla
dc.contributor.authorDiniz, Jaciara
dc.contributor.authorPereira, Catarina
dc.contributor.authorMachado, Diana
dc.contributor.authorRamos, Jorge
dc.contributor.authorSilva, Hugo
dc.contributor.authorAbilleira, Fernanda
dc.contributor.authorBrum, Clarice
dc.contributor.authorReis, Ana J.
dc.contributor.authorMacedo, Maíra
dc.contributor.authorScaini, João L.
dc.contributor.authorSilva, Ana B.
dc.contributor.authorEsteves, Leonardo
dc.contributor.authorMacedo, Rita
dc.contributor.authorMaltez, Fernando
dc.contributor.authorClemente, Sofia
dc.contributor.authorCoelho, Elizabeth
dc.contributor.authorViegas, Sofia
dc.contributor.authorRabna, Paulo
dc.contributor.authorRodrigues, Amabélia
dc.contributor.authorTaveira, Nuno
dc.contributor.authorJordao, Luísa
dc.contributor.authorKritski, Afrânio
dc.contributor.authore Silva, José Lapa
dc.contributor.authorMokrousov, Igor
dc.contributor.authorCouvin, David
dc.contributor.authorRastogi, Nalin
dc.contributor.authorCouto, Isabel
dc.contributor.authorPain, Arnab
dc.contributor.authorMcNerney, Ruth
dc.contributor.authorClark, Taane G.
dc.contributor.authorvon Groll, Andrea
dc.contributor.authorDalla-Costa, Elis R.
dc.contributor.authorRossetti, Maria Lúcia
dc.contributor.authorda Silva, Pedro E.A.
dc.contributor.authorViveiros, Miguel
dc.contributor.authorPortugal, Isabel
dc.date.accessioned2018-03-20T12:34:03Z
dc.date.available2018-03-20T12:34:03Z
dc.date.issued2018-03-18
dc.identifier.citationPerdigão J, Silva C, Diniz J, Pereira C, Machado D, et al. (2018) Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries. Infection, Genetics and Evolution. Available: http://dx.doi.org/10.1016/j.meegid.2018.03.011.
dc.identifier.issn1567-1348
dc.identifier.pmid29559379
dc.identifier.doi10.1016/j.meegid.2018.03.011
dc.identifier.urihttp://hdl.handle.net/10754/627361
dc.description.abstractTuberculosis (TB) remains a major health problem within the Community of Portuguese Language Speaking Countries (CPLP). Despite the marked variation in TB incidence across its member-states and continued human migratory flux between countries, a considerable gap in the knowledge on the Mycobacterium tuberculosis population structure and strain circulation between the countries still exists. To address this, we have assembled and analysed the largest CPLP M. tuberculosis molecular and drug susceptibility dataset, comprised by a total of 1447 clinical isolates, including 423 multidrug-resistant isolates, from five CPLP countries. The data herein presented reinforces Latin American and Mediterranean (LAM) strains as the hallmark of M. tuberculosis populational structure in the CPLP coupled with country-specific differential prevalence of minor clades. Moreover, using high-resolution typing by 24-loci MIRU-VNTR, six cross-border genetic clusters were detected, thus supporting recent clonal expansion across the Lusophone space.To make this data available to the scientific community and public health authorities we developed CPLP-TB (available at http://cplp-tb.ff.ulisboa.pt), an online database coupled with web-based tools for exploratory data analysis. As a public health tool, it is expected to contribute to improved knowledge on the M. tuberculosis population structure and strain circulation within the CPLP, thus supporting the risk assessment of strain-specific trends.
dc.description.sponsorshipFinancial support was provided by the European Society of Clinical Microbiology and Infectious Diseases, for which we would like to would like to acknowledge the Study Group for Mycobacterial Infections; Fundação CAPES [PVE-CAPES. 88881.064961/2014-01- Jose R. Lapa e Silva/UFRJ coordinator]; Genotyping and susceptibility profile of Mycobacterium tuberculosis clinical isolates from Rio Grande, Brazil were funded by Apoio a Projetos de Pesquisa em Doenças Negligenciadas, Brazil/MCTI/CNPq/MS-SCTIE – Decit [404081/2012-6] and by Programa Pesquisa para o SUS – PPSUS - FAPERGS/MS/CNPq/SESRS [1193-2551/13-6]; MIRU-VNTR typing and spoligotyping of Mycobacterium tuberculosis clinical isolates from Porto Alegre, Brazil were funded by National Council of Research [CNPq/MCTI/Universal - Project number: 441499/2014-7]; Fundação para a Ciência e a Tecnologia (FCT) Portugal [PTDC/SAU-EPI/122400/2010], part of the EDCTP2 program supported by the European Union; Fundação Calouste Gulbenkian, Portugal [Project ref. P-99934]. JP was supported by a post doc fellowship from project [PTDC/SAU-EPI/122400/2010] and by fellowship [SFRH/BPD/95406/2013] from FCT. The phylogenetic analysis work at Nalin Rastogi's lab was supported by a FEDER grant financed by the European Union and Guadeloupe Region (Programme Opérationnel FEDER-Guadeloupe-Conseil Régional 2014-2020, Grant number 2015-FED-192). IM was supported by Russian Science Foundation (grant 14-14-00292). AP was supported by a faculty baseline funding from KAUST [BAS/1/1020-01-01]. DM was supported by FCT fellowship [SFRH/BPD/100688/2014] and DM, IC MV are thankful to [GHTM UID/Multi/04413/20139] from FCT and to projects “ForDILAB-TB” and “A implementação de um novo método de identificação rápida do complexo M. tuberculosis nos Laboratórios de Referência da Tuberculose de Maputo e Beira” from Fundação Calouste Gulbenkian and the Community of the Portuguese Speaking Countries (CPLP). CS was supported by FCT [SFRH/BD/73579/2010]. TC is funded by the Medical Research Council UK (Grant no. MR/K000551/1 and MR/M01360X/1, MR/N010469/1, MC_PC_15103).
dc.publisherElsevier BV
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S1567134818301023
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Infection, Genetics and Evolution. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Infection, Genetics and Evolution, 17 March 2018. DOI: 10.1016/j.meegid.2018.03.011. © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMIRU-VNTR
dc.subjectSpoligotyping
dc.subjectTuberculosis
dc.subjectDrug resistance
dc.subjectMigration
dc.subjectMycobacteria
dc.subjectLAM
dc.titleClonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentPathogen Genomics Laboratory
dc.identifier.journalInfection, Genetics and Evolution
dc.eprint.versionPost-print
dc.contributor.institutioniMed.ULisboa – Instituto de Investigação do Medicamento, Faculdade de Farmácia, Universidade de Lisboa, Lisboa, Portugal
dc.contributor.institutionNúcleo de Pesquisa em Microbiologia Médica, Faculdade de Medicina, Universidade Federal do Rio Grande, Rio Grande, Rio Grande do Sul, Brazil
dc.contributor.institutionUnidade de Microbiologia Médica, Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal
dc.contributor.institutionCentro de Desenvolvimento Científico e Tecnológico (CDCT), Porto Alegre, Brazil
dc.contributor.institutionDepartamento de Doenças Infecciosas, Instituto Nacional de Saúde Dr. Ricardo Jorge, Lisboa, Portugal
dc.contributor.institutionServiço de Doenças Infecciosas, Hospital de Curry Cabral, Lisboa, Portugal
dc.contributor.institutionHospital da Divina Providência, Serviço de Doenças Infecciosas, Luanda, Angola
dc.contributor.institutionPrograma Nacional de Controlo da Tuberculose, Ministério da Saúde de Moçambique, Mozambique
dc.contributor.institutionInstituto Nacional de Saúde, Ministério da Saúde de Moçambique, Mozambique
dc.contributor.institutionInstituto Nacional de Saúde Pública, Projecto de Saúde de Bandim (INASA/PSB), Bissau, Guinea-Bissau
dc.contributor.institutionCentro de Investigação Interdisciplinar Egas Moniz, Instituto Superior de Ciências da Saúde Egas Moniz, Monte de Caparica, Portugal
dc.contributor.institutionAcademic Tuberculosis Program, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
dc.contributor.institutionThoracic Diseases Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
dc.contributor.institutionLaboratory of Molecular Epidemiology and Evolutionary Genetics (former Laboratory of Molecular Microbiology), St Petersburg Pasteur Institute, St Petersburg, Russia
dc.contributor.institutionWHO Supranational TB Reference Laboratory, Tuberculosis and Mycobacteria Unit, Institut Pasteur de la Guadeloupe, Morne Jolivière Abymes, Guadeloupe, France
dc.contributor.institutionLung Infection and Immunity Unit, UCT Lung Institute, University of Cape Town, Groote Schuur Hospital, Observatory, 7925, Cape Town, South Africa
dc.contributor.institutionLondon School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
dc.contributor.institutionUniversidade Luterana do Brasil (ULBRA/RS), Porto Alegre, Brazil
kaust.personPain, Arnab
kaust.grant.numberBAS/1/1020-01-01
refterms.dateFOA2019-03-17T00:00:00Z
dc.date.published-online2018-03-18
dc.date.published-print2018-03


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