CO 2 as versatile carbonation agent of glycosides: Synthesis of 5- and 6-membered cyclic glycocarbonates and investigation of their ring-opening
KAUST DepartmentPhysical Sciences and Engineering (PSE) Division
Chemical Science Program
KAUST Catalysis Center (KCC)
KAUST Grant NumberBAS/1/1374-01-01
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AbstractThis study demonstrates the successful use of CO as versatile carbonation agent for the synthesis of 5-membered and 6-membered bicyclic glycocarbonates from methyl α-d-mannopyranoside (MDM) and methyl α-d-galactopyranoside (MDG). On the one hand, these two sugars were cyclized into 5-membered glycocarbonates by mere reaction of CO with their hydroxyls either at cis-2,3 or cis-3,4 positions and without resorting to phosgene or its derivatives. The reactivity of the obtained 5-membered cyclic glycocarbonates were further tested with hexyl- and dodecyl amine. The self-assembling behavior of the formed alkyl glycosides in water was investigated and characterized by transmission electron microscope (TEM). On the other hand, secondary hydroxyls at 2- and 3- positions in MDM and MDG were first protected by a ketal group and by two ether, respectively before subjecting their respective 6-position hydroxyl to bromination. Their respective 6-bromo and 4-hydroxyl functions were subsequently reacted in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and CO. The resulting 6-membered cyclic glycocarbonates were then polymerized using 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) or DBU as organocatalyst. All the synthesized 5- and 6-membered cyclic glycocarbonates and polyglycocarbonates were thoroughly characterized by FT-IR, H, C NMR and MALDI-ToF and Gel Permeation Chromatography (GPC).
CitationPati D, Feng X, Hadjichristidis N, Gnanou Y (2018) CO 2 as versatile carbonation agent of glycosides: Synthesis of 5- and 6-membered cyclic glycocarbonates and investigation of their ring-opening. Journal of CO2 Utilization 24: 564–571. Available: http://dx.doi.org/10.1016/j.jcou.2018.02.008.
SponsorsThis research work is supported by KAUST under baseline funding (BAS/1/1374-01-01).
JournalJournal of CO2 Utilization