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Asymmetric Organocatalysis and Photoredox Catalysis for the α-Functionalization of Tetrahydroisoquinolines

dc.contributor.authorHou, Hong
dc.contributor.authorZhu, Shaoqun
dc.contributor.authorAtodiresei, Iuliana
dc.contributor.authorRueping, Magnus
dc.date.accessioned2018-03-18T10:16:01Z
dc.date.available2018-03-18T10:16:01Z
dc.date.issued2018-03-14
dc.identifier.citationHou H, Zhu S, Atodiresei I, Rueping M (2018) Asymmetric Organocatalysis and Photoredox Catalysis for the α-Functionalization of Tetrahydroisoquinolines. European Journal of Organic Chemistry 2018: 1277–1280. Available: http://dx.doi.org/10.1002/ejoc.201800117.
dc.identifier.issn1434-193X
dc.identifier.doi10.1002/ejoc.201800117
dc.identifier.urihttp://hdl.handle.net/10754/627347
dc.description.abstractThe asymmetric α-alkylation of tetrahydroisoquinolines with cyclic ketones has been accomplished in the presence of a combined catalytic system consisting of a visible-light photoredox catalyst and a chiral primary amine organocatalyst. The desired products were obtained in good yields, high enantioselectivity, and good to excellent diastereoselectivity. (PC: photoredox cycle, EN: enamine cycle).
dc.description.sponsorshipH. H. and S. Z. are grateful to the Chinese Scholarship Council for fellowships. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013)/ ERC Grant Agreement no. 617044 (SunCatChem).
dc.publisherWiley
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/ejoc.201800117
dc.rightsThis is the peer reviewed version of the following article: Asymmetric Organocatalysis and Photoredox Catalysis for the α-Functionalization of Tetrahydroisoquinolines, which has been published in final form at http://doi.org/10.1002/ejoc.201800117. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
dc.titleAsymmetric Organocatalysis and Photoredox Catalysis for the α-Functionalization of Tetrahydroisoquinolines
dc.typeArticle
dc.contributor.departmentChemical Science Program
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalEuropean Journal of Organic Chemistry
dc.eprint.versionPost-print
dc.contributor.institutionSchool of chemistry and chemical engineering; Yangzhou University; 225009 Yangzhou P. R. China
dc.contributor.institutionInstitute of Organic Chemistry; RWTH Aachen University; Landoltweg 1 52074 Aachen Germany
kaust.personRueping, Magnus
dc.relation.issupplementedbyDOI:10.5517/ccdc.csd.cc1z2fgy
display.relations<b>Is Supplemented By:</b><br/> <ul><li><i>[Dataset]</i> <br/> Hou, Hong, Zhu, Shaoqun, Atodiresei, Iuliana, &amp; Rueping, Magnus. (2018). <i>CCDC 1819590: Experimental Crystal Structure Determination</i> [Data set]. Cambridge Crystallographic Data Centre. https://doi.org/10.5517/CCDC.CSD.CC1Z2FGY. DOI: <a href="https://doi.org/10.5517/ccdc.csd.cc1z2fgy" >10.5517/ccdc.csd.cc1z2fgy</a> Handle: <a href="http://hdl.handle.net/10754/664054" >10754/664054</a></a></li></ul>
dc.date.published-online2018-03-14
dc.date.published-print2018-03-14


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