Asymmetric Organocatalysis and Photoredox Catalysis for the α-Functionalization of Tetrahydroisoquinolines
KAUST DepartmentPhysical Sciences and Engineering (PSE) Division
Chemical Science Program
KAUST Catalysis Center (KCC)
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AbstractThe asymmetric α‐alkylation of tetrahydroisoquinolines with cyclic ketones has been accomplished in the presence of a combined catalytic system consisting of a visible‐light photoredox catalyst and a chiral primary amine organocatalyst. The desired products were obtained in good yields, high enantioselectivity, and good to excellent diastereoselectivity. (PC: photoredox cycle, EN: enamine cycle).
CitationHou H, Zhu S, Atodiresei I, Rueping M (2018) Asymmetric Organocatalysis and Photoredox Catalysis for the α-Functionalization of Tetrahydroisoquinolines. European Journal of Organic Chemistry 2018: 1277–1280. Available: http://dx.doi.org/10.1002/ejoc.201800117.
SponsorsH. H. and S. Z. are grateful to the Chinese Scholarship Council for fellowships. The research leading to these results has received funding from the European Research Council under the European Union's Seventh Framework Programme (FP/2007‐2013)/ ERC Grant Agreement no. 617044 (SunCatChem).