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dc.contributor.authorMarasca, Federica
dc.contributor.authorBodega, Beatrice
dc.contributor.authorOrlando, Valerio
dc.date.accessioned2018-03-15T11:35:53Z
dc.date.available2018-03-15T11:35:53Z
dc.date.issued2018-03-09
dc.identifier.citationMarasca F, Bodega B, Orlando V (2018) How Polycomb-Mediated Cell Memory Deals With a Changing Environment. BioEssays: 1700137. Available: http://dx.doi.org/10.1002/bies.201700137.
dc.identifier.issn0265-9247
dc.identifier.pmid29522656
dc.identifier.doi10.1002/bies.201700137
dc.identifier.urihttp://hdl.handle.net/10754/627331
dc.description.abstractCells and tissues are continuously exposed to a changing microenvironment, hence the necessity of a flexible modulation of gene expression that in complex organism have been achieved through specialized chromatin mechanisms. Chromatin-based cell memory enables cells to maintain their identity by fixing lineage specific transcriptional programs, ensuring their faithful transmission through cell division; in particular PcG-based memory system evolved to maintain the silenced state of developmental and cell cycle genes. In evolution the complexity of this system have increased, particularly in vertebrates, indicating combinatorial and dynamic properties of Polycomb proteins, in some cases even overflowing outside the cell nucleus. Therefore, their function may not be limited to the imposition of rigid states of genetic programs, but on the ability to recognize signals and allow plastic transcriptional changes in response to different stimuli. Here, we discuss the most novel PcG mediated memory functions in facing and responding to the challenges posed by a fluctuating environment.
dc.description.sponsorshipBeatrice Bodega and Valerio Orlando contributed equally to this work. We thank Chiara Lanzuolo and Alice Cortesi for helpful comments and criticisms on the manuscript. The work is supported by EPIGEN Italian flagship program (to BB), Istituto Nazionale di Genetica Molecolare to BB and King Abdullah University of Science and Technology (KAUST) to VO.
dc.publisherWiley
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/bies.201700137/full
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleHow Polycomb-Mediated Cell Memory Deals With a Changing Environment
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalBioEssays
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionIstituto Nazionale di Genetica Molecolare (INGM) “Romeo and Enrica Invernizzi”; Milan 20122 Italy
kaust.personOrlando, Valerio
refterms.dateFOA2018-06-14T03:52:40Z
dc.date.published-online2018-03-09
dc.date.published-print2018-04


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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Except where otherwise noted, this item's license is described as This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.