How Polycomb-Mediated Cell Memory Deals With a Changing Environment
KAUST DepartmentBiological and Environmental Sciences and Engineering (BESE) Division
Permanent link to this recordhttp://hdl.handle.net/10754/627331
MetadataShow full item record
AbstractCells and tissues are continuously exposed to a changing microenvironment, hence the necessity of a flexible modulation of gene expression that in complex organism have been achieved through specialized chromatin mechanisms. Chromatin-based cell memory enables cells to maintain their identity by fixing lineage specific transcriptional programs, ensuring their faithful transmission through cell division; in particular PcG-based memory system evolved to maintain the silenced state of developmental and cell cycle genes. In evolution the complexity of this system have increased, particularly in vertebrates, indicating combinatorial and dynamic properties of Polycomb proteins, in some cases even overflowing outside the cell nucleus. Therefore, their function may not be limited to the imposition of rigid states of genetic programs, but on the ability to recognize signals and allow plastic transcriptional changes in response to different stimuli. Here, we discuss the most novel PcG mediated memory functions in facing and responding to the challenges posed by a fluctuating environment.
CitationMarasca F, Bodega B, Orlando V (2018) How Polycomb-Mediated Cell Memory Deals With a Changing Environment. BioEssays: 1700137. Available: http://dx.doi.org/10.1002/bies.201700137.
SponsorsBeatrice Bodega and Valerio Orlando contributed equally to this work. We thank Chiara Lanzuolo and Alice Cortesi for helpful comments and criticisms on the manuscript. The work is supported by EPIGEN Italian flagship program (to BB), Istituto Nazionale di Genetica Molecolare to BB and King Abdullah University of Science and Technology (KAUST) to VO.
Except where otherwise noted, this item's license is described as This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
- PcG-mediated higher-order chromatin structures modulate replication programs at the Drosophila BX-C.
- Authors: Lo Sardo F, Lanzuolo C, Comoglio F, De Bardi M, Paro R, Orlando V
- Issue date: 2013
- Kicking against the PRCs - A Domesticated Transposase Antagonises Silencing Mediated by Polycomb Group Proteins and Is an Accessory Component of Polycomb Repressive Complex 2.
- Authors: Liang SC, Hartwig B, Perera P, Mora-García S, de Leau E, Thornton H, de Lima Alves F, Rappsilber J, Yang S, James GV, Schneeberger K, Finnegan EJ, Turck F, Goodrich J
- Issue date: 2015 Dec
- Variations on a theme: Polycomb group proteins in plants.
- Authors: Derkacheva M, Hennig L
- Issue date: 2014 Jun
- Expansion of the polycomb system and evolution of complexity.
- Authors: Sowpati DT, Ramamoorthy S, Mishra RK
- Issue date: 2015 Nov
- Nucleotide substitutions revealing specific functions of Polycomb group genes.
- Authors: Bajusz I, Sipos L, Pirity MK
- Issue date: 2015 Apr