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    PCNA Structure and Interactions with Partner Proteins

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    Type
    Book Chapter
    Authors
    Oke, Muse
    Zaher, Manal cc
    Hamdan, Samir cc
    KAUST Department
    Biological and Environmental Science and Engineering (BESE) Division
    Bioscience Program
    Center for Desert Agriculture
    Laboratory of DNA Replication and Recombination
    Date
    2018-01-30
    Online Publication Date
    2018-01-30
    Print Publication Date
    2018
    Permanent link to this record
    http://hdl.handle.net/10754/627270
    
    Metadata
    Show full item record
    Abstract
    Proliferating cell nuclear antigen (PCNA) consists of three identical monomers that topologically encircle double-stranded DNA. PCNA stimulates the processivity of DNA polymerase δ and, to a less extent, the intrinsically highly processive DNA polymerase ε. It also functions as a platform that recruits and coordinates the activities of a large number of DNA processing proteins. Emerging structural and biochemical studies suggest that the nature of PCNA-partner proteins interactions is complex. A hydrophobic groove at the front side of PCNA serves as a primary docking site for the consensus PIP box motifs present in many PCNA-binding partners. Sequences that immediately flank the PIP box motif or regions that are distant from it could also interact with the hydrophobic groove and other regions of PCNA. Posttranslational modifications on the backside of PCNA could add another dimension to its interaction with partner proteins. An encounter of PCNA with different DNA structures might also be involved in coordinating its interactions. Finally, the ability of PCNA to bind up to three proteins while topologically linked to DNA suggests that it would be a versatile toolbox in many different DNA processing reactions.
    Citation
    Oke M, Zaher MS, Hamdan SM (2018) PCNA Structure and Interactions with Partner Proteins. Molecular Life Sciences: 866–872. Available: http://dx.doi.org/10.1007/978-1-4614-1531-2_138.
    Publisher
    Springer Nature
    Journal
    Molecular Life Sciences
    DOI
    10.1007/978-1-4614-1531-2_138
    10.1007/978-1-4614-6436-5_138-1
    Additional Links
    http://link.springer.com/chapter/10.1007/978-1-4614-1531-2_138
    ae974a485f413a2113503eed53cd6c53
    10.1007/978-1-4614-1531-2_138
    Scopus Count
    Collections
    Biological and Environmental Science and Engineering (BESE) Division; Bioscience Program; Book Chapters; Center for Desert Agriculture

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