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dc.contributor.authorLing, Yu
dc.contributor.authorSerano, Natalia Lorena Gorron
dc.contributor.authorGao, Ge
dc.contributor.authorAtia, Mohamed
dc.contributor.authorMokhtar, Morad
dc.contributor.authorWoo, Yong
dc.contributor.authorBazin, Jeremie
dc.contributor.authorVeluchamy, Alaguraj
dc.contributor.authorBenhamed, Moussa
dc.contributor.authorCrespi, Martin
dc.contributor.authorGehring, Christoph A
dc.contributor.authorReddy, A S N
dc.contributor.authorMahfouz, Magdy M.
dc.date.accessioned2018-02-27T09:00:13Z
dc.date.available2018-02-27T09:00:13Z
dc.date.issued2018-02-27
dc.identifier.citationLing Y, Serrano N, Gao G, Atia M, Mokhtar M, et al. (2018) Thermopriming Triggers Splicing Memory in Arabidopsis. Journal of Experimental Botany. Available: http://dx.doi.org/10.1093/jxb/ery062.
dc.identifier.issn0022-0957
dc.identifier.issn1460-2431
dc.identifier.pmid29474581
dc.identifier.doi10.1093/jxb/ery062
dc.identifier.urihttp://hdl.handle.net/10754/627209
dc.description.abstractAbiotic and biotic stresses limit crop productivity. Exposure to a non-lethal stress, referred to as priming, can allow plants to survive subsequent and otherwise lethal conditions; the priming effect persists even after a prolonged stress-free period. However, the molecular mechanisms underlying priming are not fully understood. Here, we investigated the molecular basis of heat shock memory and the role of priming in Arabidopsisthaliana. Comprehensive analysis of transcriptome-wide changes in gene expression and alternative splicing in primed and non-primed plants revealed that alternative splicing functions as a novel component of heat shock memory. We show that priming of plants with a non-lethal heat stress results in de-repression of splicing after a second exposure to heat stress. By contrast, non-primed plants showed significant repression of splicing. These observations link ‘splicing memory’ to the ability of plants to survive subsequent and otherwise lethal heat stress. This newly discovered priming-induced splicing memory may represent a general feature of heat stress responses in plants and other organisms as many of the key components of heat shock responses are conserved among eukaryotes. Furthermore, this finding could facilitate the development of novel approaches to improve plant survival under extreme heat stress.
dc.description.sponsorshipWe would like to thank members of the Bioscience core facility of KAUST for their help with RNA-sequencing. We would like to thank members of the laboratory for genome engineering for their discussion and technical support. This study was supported by King Abdullah University of Science and Technology (KAUST).
dc.publisherOxford University Press (OUP)
dc.relation.urlhttps://academic.oup.com/jxb/advance-article/doi/10.1093/jxb/ery062/4883206
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHeat priming
dc.subjectheat responses
dc.subjectheat stress
dc.subjectstress memory
dc.subjectalternative splicing
dc.subjectArabidopsis thaliana
dc.subjectadaptation
dc.titleThermopriming Triggers Splicing Memory in Arabidopsis
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentDesert Agriculture Initiative
dc.contributor.departmentLaboratory for Genome Engineering
dc.contributor.departmentPlant Science
dc.identifier.journalJournal of Experimental Botany
dc.eprint.versionPost-print
dc.contributor.institutionAgricultural Genetic Engineering Research Institute (AGERI), Giza Egypt
dc.contributor.institutionInstitut des Sciences du Végétal (ISV), CNRS, UPR2355, Saclay Plant Sciences, Gif-sur-Yvette Cedex, France
dc.contributor.institutionDepartment of Biology, Program in Molecular Plant Biology, Program in Cell and Molecular Biology, Colorado State University, Fort Collins, CO, USA
kaust.personLing, Yu
kaust.personSerano, Natalia Lorena Gorron
kaust.personGao, Ge
kaust.personWoo, Yong
kaust.personVeluchamy, Alaguraj
kaust.personBenhamed, Moussa
kaust.personGehring, Christoph A.
kaust.personMahfouz, Magdy M.
refterms.dateFOA2018-06-14T03:51:07Z
dc.date.published-online2018-02-27
dc.date.published-print2018-04-27


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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.