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dc.contributor.authorLiew, Yi Jin
dc.contributor.authorHowells, Emily J.
dc.contributor.authorWang, Xin
dc.contributor.authorMichell, Craig
dc.contributor.authorBurt, John A.
dc.contributor.authorIdaghdour, Youssef
dc.contributor.authorAranda, Manuel
dc.date.accessioned2020-02-12T11:54:03Z
dc.date.available2018-02-27T09:00:11Z
dc.date.available2020-02-12T11:54:03Z
dc.date.issued2020-02-10
dc.date.submitted2018-03-20
dc.identifier.citationLiew, Y. J., Howells, E. J., Wang, X., Michell, C. T., Burt, J. A., Idaghdour, Y., & Aranda, M. (2020). Intergenerational epigenetic inheritance in reef-building corals. Nature Climate Change. doi:10.1038/s41558-019-0687-2
dc.identifier.doi10.1038/s41558-019-0687-2
dc.identifier.doi10.1101/269076
dc.identifier.urihttp://hdl.handle.net/10754/627197
dc.description.abstractThe perception that the inheritance of phenotypic traits operates solely through genetic means is slowly being eroded: epigenetic mechanisms have been shown to induce heritable changes in gene activity in plants1,2 and metazoans1,3. Inheritance of DNA methylation patterns provides a potential pathway for environmentally induced phenotypes to contribute to evolution of species and populations1,2,3,4,5. However, in basal metazoans, it is unknown whether inheritance of CpG methylation patterns occurs across the genome (as in plants) or as rare exceptions (as in mammals)4. Here, we show that DNA methylation patterns in a reef-building coral are determined by genotype and developmental stage, as well as by parental environment. Transmission of CpG methylation from adults to their sperm and larvae demonstrates genome-wide inheritance. Variation in the hypermethylation of genes in adults and their sperm from distinct environments suggests intergenerational acclimatization to local temperature and salinity. Furthermore, genotype-independent adjustments of methylation levels in stress-related genes were strongly correlated with offspring survival rates under heat stress. These findings support a role of DNA methylation in the intergenerational inheritance of traits in corals, which could extend to enhancing their capacity to adapt to climate change.
dc.description.sponsorshipWe thank D. Abrego, G. Vaughan and D. McParland for assistance with fieldwork, coral spawning and the collection of environmental data. We thank the NYUAD Core Research Vessel and The Palms Dive Center for fieldwork support. We thank the Environment Agency Abu Dhabi and Fujairah Municipality for research permits and the KAUST Sequencing Core Facility for the sequencing of the libraries. The research reported in this publication was supported by the KAUST OSR under grant no. URF/1/3447-01-01, as well as baseline support to M.A.; and by NYUAD research grant no. AD105 to Y.I.
dc.publisherSpringer Science and Business Media LLC
dc.relation.urlhttp://www.nature.com/articles/s41558-019-0687-2
dc.relation.urlhttps://rdcu.be/b1AtI
dc.rightsThis is the BioRxiv preprint. The final published version is available from Nature Climate Change at: https://rdcu.be/b1AtI
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectEpigenetics
dc.subjectDNA methylation
dc.subjectcoral
dc.subjectcnidarian
dc.subjectintergenerational inheritance
dc.titleIntergenerational epigenetic inheritance in reef-building corals
dc.typeArticle
dc.contributor.departmentRed Sea Research Center (RSRC)
dc.contributor.departmentMarine Science Program
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.identifier.journalNature Climate Change
dc.eprint.versionPre-print
dc.contributor.institutionPresent address: CSIRO Health & Biosecurity, North Ryde, New South Wales, Australia.
dc.contributor.institutionCenter for Genomics and Systems Biology and Program in Biology, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.
dc.contributor.institutionPresent address: Centre for Sustainable Ecosystem Solutions, School of Earth, Atmospheric and Life Sciences, University of Wollongong, Wollongong, New South Wales, Australia.
dc.contributor.institutionPresent address: Center for Cardiovascular Regeneration, Houston Methodist, Houston, TX, USA.
dc.contributor.institutionPresent address: Department of Environmental and Biological Sciences, University of Eastern Finland, Joensuu, Finland.
kaust.personLiew, Yi Jin
kaust.personWang, Xin
kaust.personMichell, Craig
kaust.personAranda, Manuel
kaust.grant.numberURF/1/3447-01-01
dc.date.accepted2019-12-19
refterms.dateFOA2018-06-14T03:51:00Z
kaust.acknowledged.supportUnitKAUST Sequencing Core Facility
kaust.acknowledged.supportUnitOSR
dc.date.posted2018-02-22


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This is the BioRxiv preprint. The final published version is available from Nature Climate Change at: https://rdcu.be/b1AtI
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