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dc.contributor.authorLiew, Yi Jin
dc.contributor.authorHowells, Emily J.
dc.contributor.authorWang, Xin
dc.contributor.authorMichell, Craig
dc.contributor.authorBurt, John A.
dc.contributor.authorIdaghdour, Youssef
dc.contributor.authorAranda, Manuel
dc.date.accessioned2018-02-27T09:00:11Z
dc.date.available2018-02-27T09:00:11Z
dc.date.issued2018-02-22
dc.identifier.citationLiew YJ, Howells EJ, Wang X, Michell CT, Burt JA, et al. (2018) Intergenerational epigenetic inheritance in reef-building corals. Available: http://dx.doi.org/10.1101/269076.
dc.identifier.doi10.1101/269076
dc.identifier.urihttp://hdl.handle.net/10754/627197.1
dc.description.abstractThe notion that intergenerational or transgenerational inheritance operates solely through genetic means is slowly being eroded: epigenetic mechanisms have been shown to induce heritable changes in gene activity in plants and metazoans. Inheritance of DNA methylation provides a potential pathway for environmentally induced phenotypes to contribute to evolution of species and populations. However, in basal metazoans, it is unknown whether inheritance of CpG methylation patterns occurs across the genome (as in plants) or as rare exceptions (as in mammals). Here, we demonstrate genome-wide intergenerational transmission of CpG methylation patterns from parents to sperm and larvae in a reef-building coral. We also show variation in hypermethylated genes in corals from distinct environments, indicative of responses to variations in temperature and salinity. These findings support a role of DNA methylation in the transgenerational inheritance of traits in corals, which may extend to enhancing their capacity to adapt to climate change.
dc.description.sponsorshipWe thank D. Abrego, G. Vaughan, and D. McParland for assistance with fieldwork, coral spawning, and the collection of environmental data, as well as the KAUST Sequencing Core Facility for the sequencing of the libraries. This work was financially supported by KAUST (sequencing and bioinformatics) and NYUAD (fieldwork and coral spawning).
dc.publisherCold Spring Harbor Laboratory
dc.relation.urlhttps://www.biorxiv.org/content/early/2018/02/21/269076
dc.rightsThe copyright holder for this preprint is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license.
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectEpigenetics
dc.subjectDNA methylation
dc.subjectcoral
dc.subjectcnidarian
dc.subjectintergenerational inheritance
dc.titleIntergenerational epigenetic inheritance in reef-building corals
dc.typePreprint
dc.contributor.departmentRed Sea Research Center (RSRC)
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentMarine Science Program
dc.eprint.versionPre-print
dc.contributor.institutionCenter for Genomics and Systems Biology, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.
kaust.personLiew, Yi Jin
kaust.personWang, Xin
kaust.personMichell, Craig
kaust.personAranda, Manuel
dc.relation.issupplementedbybioproject:PRJNA430328
dc.relation.issupplementedbygithub:lyijin/working_with_dna_meth
dc.relation.issupplementedbyDOI:10.5281/zenodo.3558476
refterms.dateFOA2018-06-14T03:51:00Z
display.relations<b>Is Supplemented By:</b><br/> <ul><li><i>[Bioproject]</i> <br/> Title: Intergenerational epigenetic inheritance in Platygyra daedalea. Publication Date: 2018-01-17. bioproject: <a href="https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA430328" >PRJNA430328</a> Handle: <a href="http://hdl.handle.net/10754/666487" >10754/666487</a></a></li><li><i>[Software]</i> <br/> Title: lyijin/working_with_dna_meth: Pipeline that I use to process DNA methylation data--both theory and implementation included!. Publication Date: 2017-08-28. github: <a href="https://github.com/lyijin/working_with_dna_meth" >lyijin/working_with_dna_meth</a> Handle: <a href="http://hdl.handle.net/10754/666993" >10754/666993</a></a></li><li><i>[Software]</i> <br/> Liew, Y. J. (2019). <i>lyijin/pdae_dna_meth: 1.0.0</i> (Version 1.0.0) [Computer software]. Zenodo. https://doi.org/10.5281/ZENODO.3558476. DOI: <a href="https://doi.org/10.5281/zenodo.3558476" >10.5281/zenodo.3558476</a> Handle: <a href="http://hdl.handle.net/10754/666995" >10754/666995</a></a></li></ul>


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