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dc.contributor.authorHasan, Mohammed Nihal
dc.contributor.authorChoudhry, Hani
dc.contributor.authorRazvi, Syed Shoeb
dc.contributor.authorMoselhy, Said Salama
dc.contributor.authorKumosani, Taha Abduallah
dc.contributor.authorZamzami, Mazin A.
dc.contributor.authorOmran, Ziad
dc.contributor.authorHalwani, Majed A.
dc.contributor.authorAl-Babili, Salim
dc.contributor.authorAbualnaja, Khalid Omer
dc.contributor.authorAl-Malki, Abdulrahman Labeed
dc.contributor.authorAlhosin, Mahmoud
dc.contributor.authorAsami, Tadao
dc.date.accessioned2018-02-13T13:43:19Z
dc.date.available2018-02-13T13:43:19Z
dc.date.issued2018-02-09
dc.identifier.citationHasan MN, Choudhry H, Razvi SS, Moselhy SS, Kumosani TA, et al. (2018) Synthetic Strigolactone Analogues Reveal Anti-Cancer Activities on Hepatocellular Carcinoma Cells. Bioorganic & Medicinal Chemistry Letters. Available: http://dx.doi.org/10.1016/j.bmcl.2018.02.016.
dc.identifier.issn0960-894X
dc.identifier.pmid29456109
dc.identifier.doi10.1016/j.bmcl.2018.02.016
dc.identifier.urihttp://hdl.handle.net/10754/627127
dc.description.abstractHepatocellular carcinoma (HCC) remains one of the leading causes of death worldwide. The complex etiology is attributed to many factors like heredity, cirrhosis, hepatitis infections or the dysregulation of the different molecular pathways. Nevertheless, the current treatment regimens have either severe side effects or tumors gradually acquire resistance upon prolonged use. Thus, developing a new selective treatment for HCC is the need of the hour. Many anticancer agents derived from plants have been evaluated for their cytotoxicity towards many human cancer cell lines. Strigolactones (SLs)-a newly discovered class of phytohormones, play a crucial role in the development of plant-root and shoot. Recently, many synthetic analogues of SLs have demonstrated pro-apoptotic effects on different cancer cell lines like prostate, breast, colon and lung. In this study, we tested synthetic SLs analogues on HCC cell line-HepG2 and evaluated their capability to induce cell proliferation inhibition and apoptosis. Primary WST-1 assays, followed by annexin-V/7AAD staining, demonstrated the anti-proliferative effects. The SLs analogues TIT3 and TIT7 were found to significantly reduce HepG2 cell viability in a dose- and time-dependent manner and induce apoptosis. Interestingly, though TIT3 and TIT7 strongly affected cancer cell proliferation, both compounds showed moderate anti-proliferative effect on normal cells. Further, migration of cancer cells was suppressed upon treatment with TIT3 and TIT7 in a wound healing assay. In summary, these findings suggest that two SLs analogues TIT3 and TIT7 exert selective inhibitory effects on cancer cells most likely through targeting microtubules. SLs analogues could be used in future as potential anti-cancer candidates in chemotherapy.
dc.description.sponsorshipThe authors appreciate the endeavours of DSR in supporting this project financially and technically. This study was funded by the Deanship of Scientific Research (DSR), at King Abdulaziz University, Jeddah, under grant no: HiCi-1-130- 36.
dc.publisherElsevier BV
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S0960894X18301057
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Bioorganic & Medicinal Chemistry Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Bioorganic & Medicinal Chemistry Letters, [, , (2018-02-09)] DOI: 10.1016/j.bmcl.2018.02.016 . © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectStrigolactones
dc.subjectLiver cancer
dc.subjectApoptosis
dc.subjectCell proliferation
dc.subjectHepatocellular carcinoma
dc.titleSynthetic Strigolactone Analogues Reveal Anti-Cancer Activities on Hepatocellular Carcinoma Cells
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentComputational Bioscience Research Center (CBRC)
dc.contributor.departmentDesert Agriculture Initiative
dc.contributor.departmentPlant Science
dc.contributor.departmentPlant Science Program
dc.identifier.journalBioorganic & Medicinal Chemistry Letters
dc.eprint.versionPost-print
dc.contributor.institutionDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
dc.contributor.institutionBioactive Natural Products Research Group, King Abdulaziz University, Jeddah, Saudi Arabia
dc.contributor.institutionCancer and Mutagenesis Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia
dc.contributor.institutionCancer Metabolism and Epigenetic Unit, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
dc.contributor.institutionBiochemistry Department, Faculty of Science, Ain shams University, Cairo, Egypt
dc.contributor.institutionExperimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia
dc.contributor.institutionProduction of Bioproducts for Industrial Applications Research Group, King Abdulaziz University, Jeddah, Saudi Arabia
dc.contributor.institutionCollege of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia
dc.contributor.institutionNanomedicine Department, King Abdullah International Medical Research Center (KAIMRC), King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia
dc.contributor.institutionGraduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo 113–8657, Japan
kaust.personAl-Babili, Salim
dc.date.published-online2018-02-09
dc.date.published-print2018-04


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