Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?
Type
ArticleAuthors
Vasaikar, SuhasTsipras, Giorgos
Landázuri, Natalia
Costa, Helena
Wilhelmi, Vanessa
Scicluna, Patrick
Cui, Huanhuan L.
Mohammad, Abdul-Aleem
Davoudi, Belghis
Shang, Mingmei
Ananthaseshan, Sharan
Strååt, Klas
Stragliotto, Giuseppe
Rahbar, Afsar
Wong, Kum Thong
Tegner, Jesper

Yaiw, Koon-Chu

Söderberg-Naucler, Cecilia
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionBioscience Program
Computer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
Date
2018-02-06Online Publication Date
2018-02-06Print Publication Date
2018-12Permanent link to this record
http://hdl.handle.net/10754/627076
Metadata
Show full item recordAbstract
BackgroundGlioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed. Since overexpression of endothelin B receptor (ETBR) has been demonstrated in gliomas, we aimed to test whether ETBR is a useful prognostic marker in GBM and examine if the clinically available endothelin receptor antagonists (ERA) could be useful in the disease treatment.MethodsData from The Cancer Genome Atlas and the Gene Expression Omnibus database were analyzed to assess ETBR expression. For survival analysis, glioblastoma samples from 25 Swedish patients were immunostained for ETBR, and the findings were correlated with clinical history. The druggability of ETBR was assessed by protein-protein interaction network analysis. ERAs were analyzed for toxicity in in vitro assays with GBM and breast cancer cells.ResultsBy bioinformatics analysis, ETBR was found to be upregulated in glioblastoma patients, and its expression levels were correlated with reduced survival. ETBR interacts with key proteins involved in cancer pathogenesis, suggesting it as a druggable target. In vitro viability assays showed that ERAs may hold promise to treat glioblastoma and breast cancer.ConclusionsETBR is overexpressed in glioblastoma and other cancers and may be a prognostic marker in glioblastoma. ERAs may be useful for treating cancer patients.Citation
Vasaikar S, Tsipras G, Landázuri N, Costa H, Wilhelmi V, et al. (2018) Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target? BMC Cancer 18. Available: http://dx.doi.org/10.1186/s12885-018-4012-7.Sponsors
This work was supported by Sten A Olssons Foundation for Research and Culture, Family Erling-Persson Foundation, Torsten Söderberg Foundation, BILTEMA Foundation, lngaBritt and Arne Lundbergs Foundation, Stichting af Jochnick Foundation, Jane and Dan Olssons Research Foundation, Nexttobe, Swedish Cancer Foundation, Children’s Cancer Foundation, Swedish Medical Research Council, Thematic Cardiovascular Research Center and Stockholm County Council, and the Swedish Heart-Lung Foundation, VINNOVA-BIO-X and Medivir AB (all to CSN), Cure cancer /Bota Cancer (to KCY). The funding body had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.Publisher
Springer NatureJournal
BMC CancerPubMed ID
29409474Relations
Is Supplemented By:- [Dataset]
. DOI: 10.6084/m9.figshare.c.3998010.v1 HANDLE: 10754/664016
- [Dataset]
. DOI: 10.6084/m9.figshare.5862591.v1 HANDLE: 10754/664017
ae974a485f413a2113503eed53cd6c53
10.1186/s12885-018-4012-7
Scopus Count
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