Cooperative Metal–Ligand Catalyzed Intramolecular Hydroamination and Hydroalkoxylation of Allenes Using a Stable Iron Catalyst
Type
ArticleAuthors
El-Sepelgy, OsamaBrzozowska, Aleksandra
Sklyaruk, Jan
Jang, Yoon Kyung
Zubar, Viktoriia
Rueping, Magnus

KAUST Department
Chemical Science ProgramKAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Date
2018-01-18Online Publication Date
2018-01-18Print Publication Date
2018-02-02Permanent link to this record
http://hdl.handle.net/10754/626891
Metadata
Show full item recordAbstract
A new iron-catalyzed chemoselective intramolecular hydroamination and hydroalkoxylation of the readily available α-allenic amines and alcohols to valuable unsaturated 5-membered heterocycles, 2,3-dihydropyrrole and 2,3-dihydrofuran, is reported. Effective selectivity control is achieved by a metal–ligand cooperative activation of the substrates. The mild reaction conditions and the use of low amounts of an air and moisture stable iron catalyst allow for the hydrofunctionalization of a wide range of allenes bearing different functional groups in good yields in the absence of base or any sensitive additives.Citation
El-Sepelgy O, Brzozowska A, Sklyaruk J, Jang YK, Zubar V, et al. (2018) Cooperative Metal–Ligand Catalyzed Intramolecular Hydroamination and Hydroalkoxylation of Allenes Using a Stable Iron Catalyst. Organic Letters. Available: http://dx.doi.org/10.1021/acs.orglett.7b03828.Sponsors
J.S. thanks FCI for the predoctoral fellowship.Publisher
American Chemical Society (ACS)Journal
Organic LettersAdditional Links
http://pubs.acs.org/doi/10.1021/acs.orglett.7b03828ae974a485f413a2113503eed53cd6c53
10.1021/acs.orglett.7b03828