Nickel-Catalyzed C-S Bond Formation via Decarbonylative Thioetherification of Esters, Amides and Intramolecular Recombination Fragment Coupling of Thioesters
KAUST DepartmentPhysical Sciences and Engineering (PSE) Division
Chemical Science Program
KAUST Catalysis Center (KCC)
KAUST Grant NumberURF/1/3030-01
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AbstractA nickel catalyzed cross-coupling protocol for the straightforward C-S bond formation has been developed. Various mercaptans and a wide range of ester and amide substrates bearing various substituents were tolerated in this process which afforded products in good to excellent yields. Furthermore, an intramolecular protocol for the synthesis of thioethers starting from thioesters has been developed. The utility of this protocol has been demonstrated in the synthesis of benzothiophene on the bench top.
CitationLee S-C, Liao H-H, Chatupheeraphat A, Rueping M (2018) Nickel-Catalyzed C-S Bond Formation via Decarbonylative Thioetherification of Esters, Amides and Intramolecular Recombination Fragment Coupling of Thioesters. Chemistry - A European Journal. Available: http://dx.doi.org/10.1002/chem.201705842.
SponsorsH.-H. Liao gratefully acknowledges the DAAD for doctoral fellowship. This research was supported by the KAUST Office of Sponsored Research under Award No. URF/1/3030-01.
JournalChemistry - A European Journal