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dc.contributor.authorZenger, Manuel
dc.contributor.authorBurlet-Godinot, Sophie
dc.contributor.authorPetit, Jean-Marie
dc.contributor.authorMagistretti, Pierre J.
dc.date.accessioned2018-01-15T06:35:09Z
dc.date.available2018-01-15T06:35:09Z
dc.date.issued2017-07-22
dc.identifier.citationZenger M, Burlet-Godinot S, Petit J-M, Magistretti PJ (2017) Noradrenergic System and Memory. Noradrenergic Signaling and Astroglia: 183–200. Available: http://dx.doi.org/10.1016/B978-0-12-805088-0.00009-8.
dc.identifier.doi10.1016/B978-0-12-805088-0.00009-8
dc.identifier.urihttp://hdl.handle.net/10754/626794
dc.description.abstractThere is ample evidence indicating that noradrenaline plays an important role in memory mechanisms. Noradrenaline is thought to modulate these procsses through activation of adrenergic receptors in neurons. Astrocytes that form essential partners for synaptic function, also express alpha- and beta-adrenergic receptors. In astrocytes, noradrenaline triggers metabolic actions such as the glycogenolysis leading to an increase in l-lactate formation and release. l-Lactate can be used by neurons as a sourc of energy during memory tasks and can also induc transcription of plasticity genes in neurons. Activation of β-adrenergic receptors can also trigger gliotransmitter release resulting of intracllular calcium waves. These gliotransmitters modulate the synaptic activity and thereby can modulate long-term potentiation mechanisms. In summary, recnt evidencs indicate that noradrenaline exerts its memory-promoting effects through different modes of action both on neurons and astrocytes.
dc.publisherElsevier BV
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/B9780128050880000098
dc.subjectGlycogen
dc.subjectHippocampus
dc.subjectL-lactate
dc.subjectLearning
dc.subjectSleep
dc.titleNoradrenergic System and Memory
dc.typeBook Chapter
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.identifier.journalNoradrenergic Signaling and Astroglia
dc.contributor.institutionLNDC, Brain Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
dc.contributor.institutionCentre Hospitalier Universitaire Vaudois, Prilly, Switzerland
kaust.personMagistretti, Pierre J.
dc.date.published-online2017-07-22
dc.date.published-print2017


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