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    Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

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    Type
    Article
    Authors
    Croissant, Jonas G.
    Fatieiev, Yevhen cc
    Almalik, Abdulaziz
    Khashab, Niveen M. cc
    KAUST Department
    Advanced Membranes and Porous Materials Research Center
    Chemical Science Program
    Investment Fund
    Physical Science and Engineering (PSE) Division
    Smart Hybrid Materials (SHMs) lab
    Date
    2017-11-30
    Online Publication Date
    2017-11-30
    Print Publication Date
    2018-02
    Permanent link to this record
    http://hdl.handle.net/10754/626577
    
    Metadata
    Show full item record
    Abstract
    Predetermining the physico-chemical properties, biosafety, and stimuli-responsiveness of nanomaterials in biological environments is essential for safe and effective biomedical applications. At the forefront of biomedical research, mesoporous silica nanoparticles and mesoporous organosilica nanoparticles are increasingly investigated to predict their biological outcome by materials design. In this review, it is first chronicled that how the nanomaterial design of pure silica, partially hybridized organosilica, and fully hybridized organosilica (periodic mesoporous organosilicas) governs not only the physico-chemical properties but also the biosafety of the nanoparticles. The impact of the hybridization on the biocompatibility, protein corona, biodistribution, biodegradability, and clearance of the silica-based particles is described. Then, the influence of the surface engineering, the framework hybridization, as well as the morphology of the particles, on the ability to load and controllably deliver drugs under internal biological stimuli (e.g., pH, redox, enzymes) and external noninvasive stimuli (e.g., light, magnetic, ultrasound) are presented. To conclude, trends in the biomedical applications of silica and organosilica nanovectors are delineated, such as unconventional bioimaging techniques, large cargo delivery, combination therapy, gaseous molecule delivery, antimicrobial protection, and Alzheimer's disease therapy.
    Citation
    Croissant JG, Fatieiev Y, Almalik A, Khashab NM (2017) Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications. Advanced Healthcare Materials: 1700831. Available: http://dx.doi.org/10.1002/adhm.201700831.
    Publisher
    Wiley
    Journal
    Advanced Healthcare Materials
    DOI
    10.1002/adhm.201700831
    PubMed ID
    29193848
    Additional Links
    http://onlinelibrary.wiley.com/doi/10.1002/adhm.201700831/full
    ae974a485f413a2113503eed53cd6c53
    10.1002/adhm.201700831
    Scopus Count
    Collections
    Articles; Advanced Membranes and Porous Materials Research Center; Physical Science and Engineering (PSE) Division; Controlled Release and Delivery Laboratory; Chemical Science Program

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