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dc.contributor.authorLiu, Chen
dc.contributor.authorMalek, Michael
dc.contributor.authorPoon, Ivan K. H.
dc.contributor.authorJiang, Lanzhou
dc.contributor.authorSheppard, Colin J. R.
dc.contributor.authorRoberts, Ann
dc.contributor.authorQuiney, Harry
dc.contributor.authorZhang, Douguo
dc.contributor.authorYuan, Xiaocong
dc.contributor.authorLin, Jiao
dc.contributor.authorDepeursinge, Christian
dc.contributor.authorMarquet, Pierre
dc.contributor.authorKou, Shan Shan
dc.date.accessioned2017-12-28T07:32:13Z
dc.date.available2017-12-28T07:32:13Z
dc.date.issued2017-04-14
dc.identifier.urihttp://hdl.handle.net/10754/626506
dc.description.abstractHere we report a method for visualization of volumetric structural information of live biological samples with no exogenous contrast agents. The process is made possible through a technique that involves generation, synthesis and analysis of three-dimensional (3D) Fourier components of light diffracted by the sample. This leads to the direct recovery of quantitative cellular morphology with no iterative procedures for reduced computational complexity. Combing with the fact that the technique is easily adaptive to any imaging platform and requires minimum sample preparation, our proposed method is particularly promising for observing fast, volumetric and dynamic events previously only accessible through staining methods.
dc.publisherarXiv
dc.relation.urlhttp://arxiv.org/abs/1704.04445v1
dc.relation.urlhttp://arxiv.org/pdf/1704.04445v1
dc.rightsArchived with thanks to arXiv
dc.titleLabel-free three-dimensional (3D) structural imaging in live cells using intrinsic optical refractive index
dc.typePreprint
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.eprint.versionPre-print
dc.contributor.institutionDepartment of Optics and Optical Engineering, Anhui Key Laboratory of Optoelectronic Science and Technology, University of Science and Technology of China, Hefei, Anhui 230026, China.
dc.contributor.institutionDepartment of Chemistry and Physics, La Trobe Institute for Molecular Sciences (LIMS), La Trobe University, Melbourne, Victoria 3086, Australia.
dc.contributor.institutionNanophotonics Research Centre, Shenzhen University & Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
dc.contributor.institutionDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science (LIMS), La Trobe University, Melbourne, Victoria 3086, Australia.
dc.contributor.institutionIstituto Italiano di Tecnologia, Genova 16163, Italy.
dc.contributor.institutionSchool of Physics, University of Melbourne, VIC 3010 Australia.
dc.contributor.institutionSchool of Engineering, RMIT University, Melbourne, VIC 3001, Australia.
dc.contributor.institutionMicrovision and Microdiagnostic Group (SCI STI CHD), Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.
dc.contributor.institutionCentre d’optique, photonique et laser, Université Laval, Québec, Québec, Canada, Department of Psychiatry & Neuroscience, Université Laval, Québec, Québec, Canada.
dc.contributor.institutionInstitut universitaire en santé mentale de Québec, Québec, Québec, Canada.
dc.contributor.institutionJoint International Research Unit in Neurodevelopment and Child Psychiatry, CHUV, Département de Psychiatrie, Lausanne, Switzerland, Université Laval ,Québec, Québec, Canada.
dc.identifier.arxivid1704.04445
kaust.personDepeursinge, Christian
dc.versionv1
refterms.dateFOA2018-06-14T05:30:57Z


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