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dc.contributor.authorZhang, Yang
dc.contributor.authorYang, Peng
dc.contributor.authorMadathumpady Abubaker, Habeeb Muhammed
dc.contributor.authorAlsaiari, Shahad K.
dc.contributor.authorMoosa, Basem
dc.contributor.authorAlMalik, Abdulaziz
dc.contributor.authorKumar, Anjli
dc.contributor.authorRinge, Emilie
dc.contributor.authorKhashab, Niveen M.
dc.date.accessioned2017-10-19T07:10:41Z
dc.date.available2017-10-19T07:10:41Z
dc.date.issued2017-10-18
dc.identifier.citationZhang Y, Yang P, Habeeb Muhammed MA, Alsaiari SK, Moosa B, et al. (2017) Tunable and Linker Free Nanogaps in Core–Shell Plasmonic Nanorods for Selective and Quantitative Detection of Circulating Tumor Cells by SERS. ACS Applied Materials & Interfaces. Available: http://dx.doi.org/10.1021/acsami.7b10959.
dc.identifier.issn1944-8244
dc.identifier.issn1944-8252
dc.identifier.doi10.1021/acsami.7b10959
dc.identifier.urihttp://hdl.handle.net/10754/625911
dc.description.abstractControlling the size, number, and shape of nanogaps in plasmonic nanostructures is of significant importance for the development of novel quantum plasmonic devices and quantitative sensing techniques such as surface-enhanced Raman scattering (SERS). Here, we introduce a new synthetic method based on coordination interactions and galvanic replacement to prepare core-shell plasmonic nanorods with tunable enclosed nanogaps. Decorating Au nanorods with Raman reporters that strongly coordinate Ag+ ions (e.g., 4-mercaptopyridine) afforded uniform nucleation sites to form a sacrificial Ag shell. Galvanic replacement of the Ag shell by HAuCl4 resulted in Au-AgAu core-shell structure with a uniform intra-nanoparticle gap. The size (length and width) and morphology of the core-shell plasmonic nanorods as well as the nanogap size depends on the concentration of the coordination complexes formed between Ag+ ions and 4-mercaptopyridine. Moreover, encapsulating Raman reporters within the nanogaps afforded an internal standard for sensitive and quantitative SERS analysis. To test the applicability, core-shell plasmonic nanorods were functionalized with aptamers specific to circulating tumor cells such as MCF-7 (Michigan Cancer Foundation-7, breast cancer cell line). This system could selectively detect as low as 20 MCF-7 cells in a blood mimicking fluid employing SERS. The linking DNA duplex on core-shell plasmonic nanorods can also intercalate hydrophobic drug molecules such as Doxorubicin, thereby increasing the versatility of this sensing platform to include drug delivery. Our synthetic method offers the possibility of developing multifunctional SERS-active materials with a wide range of applications including bio sensing, imaging and therapy.
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttp://pubs.acs.org/doi/abs/10.1021/acsami.7b10959
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acsami.7b10959.
dc.titleTunable and Linker Free Nanogaps in Core-Shell Plasmonic Nanorods for Selective and Quantitative Detection of Circulating Tumor Cells by SERS
dc.typeArticle
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentBioscience Program
dc.contributor.departmentChemical Science Program
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.contributor.departmentSmart Hybrid Materials (SHMs) lab
dc.identifier.journalACS Applied Materials & Interfaces
dc.eprint.versionPost-print
dc.contributor.institutionLife sciences and Environment Research Institute, Center of Excellence in Nanomedicine (CENM), King Abdulaziz City for Science and Technology (KACST), Riyadh 11461, Saudi Arabia
dc.contributor.institutionDepartment of Chemistry, Rice University, Houston TX 77005, USA
dc.contributor.institutionDepartment of Materials Science and NanoEngineering, Rice University, Houston TX 77005, USA
kaust.personZhang, Yang
kaust.personYang, Peng
kaust.personMadathumpady Abubaker, Habeeb Muhammed
kaust.personAlsaiari, Shahad K.
kaust.personMoosa, Basem
kaust.personKhashab, Niveen M.
dc.date.published-online2017-10-18
dc.date.published-print2017-11


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