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dc.contributor.authorLuongo, Giovanni
dc.contributor.authorCampagnolo, Paola
dc.contributor.authorPerez, Jose E.
dc.contributor.authorKosel, Jürgen
dc.contributor.authorGeorgiou, Theoni K.
dc.contributor.authorRegoutz, Anna
dc.contributor.authorPayne, David J.
dc.contributor.authorStevens, Molly M.
dc.contributor.authorRyan, Mary P.
dc.contributor.authorPorter, Alexandra E
dc.contributor.authorDunlop, Iain E
dc.date.accessioned2017-10-19T07:10:41Z
dc.date.available2017-10-19T07:10:41Z
dc.date.issued2017-10-12
dc.identifier.citationLuongo G, Campagnolo P, Perez JE, Kosel J, Georgiou TK, et al. (2017) Scalable high-affinity stabilization of magnetic iron oxide nanostructures by a biocompatible antifouling homopolymer. ACS Applied Materials & Interfaces. Available: http://dx.doi.org/10.1021/acsami.7b12290.
dc.identifier.issn1944-8244
dc.identifier.issn1944-8252
dc.identifier.doi10.1021/acsami.7b12290
dc.identifier.urihttp://hdl.handle.net/10754/625909
dc.description.abstractIron oxide nanostructures have been widely developed for biomedical applications, due to their magnetic properties and biocompatibility. In clinical application, the stabilization of these nanostructures against aggregation and non-specific interactions is typically achieved using weakly anchored polysaccharides, with better-defined and more strongly anchored synthetic polymers not commercially adopted due to complexity of synthesis and use. Here, we show for the first time stabilization and biocompatibilization of iron oxide nanoparticles by a synthetic homopolymer with strong surface anchoring and a history of clinical use in other applications, poly(2-methacryloyloxyethy phosphorylcholine) (poly(MPC)). For the commercially important case of spherical particles, binding of poly(MPC) to iron oxide surfaces and highly effective individualization of magnetite nanoparticles (20 nm) are demonstrated. Next-generation high-aspect ratio nanowires (both magnetite/maghemite and core-shell iron/iron oxide) are furthermore stabilized by poly(MPC)-coating, with nanowire cytotoxicity at large concentrations significantly reduced. The synthesis approach is exploited to incorporate functionality into the poly(MPC) chain is demonstrated by random copolymerization with an alkyne-containing monomer for click-chemistry. Taking these results together, poly(MPC) homopolymers and random copolymers offer a significant improvement over current iron oxide nanoformulations, combining straightforward synthesis, strong surface-anchoring and well-defined molecular weight.
dc.description.sponsorshipWe acknowledge funding from a KAUST Partnership grant (JK, MMS, IED, AEP, GL, PC, JEP).
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttp://pubs.acs.org/doi/abs/10.1021/acsami.7b12290
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acsami.7b12290.
dc.titleScalable high-affinity stabilization of magnetic iron oxide nanostructures by a biocompatible antifouling homopolymer
dc.typeArticle
dc.contributor.departmentBiological and Environmental Sciences and Engineering (BESE) Division
dc.contributor.departmentBioscience Program
dc.contributor.departmentComputer, Electrical and Mathematical Sciences and Engineering (CEMSE) Division
dc.contributor.departmentElectrical Engineering Program
dc.identifier.journalACS Applied Materials & Interfaces
dc.eprint.versionPost-print
dc.contributor.institutionDepartment of Materials, Imperial College London, London SW7 2AZ, United Kingdom.
kaust.personPerez, Jose E.
kaust.personKosel, Jürgen
kaust.personPayne, David J.


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