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dc.contributor.authorBanala, Srinivas
dc.contributor.authorFokong, Stanley
dc.contributor.authorBrand, Christian
dc.contributor.authorAndreou, Chrysafis
dc.contributor.authorKräutler, Bernhard
dc.contributor.authorRueping, Magnus
dc.contributor.authorKiessling, Fabian
dc.date.accessioned2017-10-17T08:48:35Z
dc.date.available2017-10-17T08:48:35Z
dc.date.issued2017
dc.identifier.citationBanala S, Fokong S, Brand C, Andreou C, Kräutler B, et al. (2017) Quinone-fused porphyrins as contrast agents for photoacoustic imaging. Chem Sci 8: 6176–6181. Available: http://dx.doi.org/10.1039/c7sc01369h.
dc.identifier.issn2041-6520
dc.identifier.issn2041-6539
dc.identifier.doi10.1039/c7sc01369h
dc.identifier.urihttp://hdl.handle.net/10754/625873
dc.description.abstractPhotoacoustic (PA) imaging is an emerging non-invasive diagnostic modality with many potential clinical applications in oncology, rheumatology and the cardiovascular field. For this purpose, there is a high demand for exogenous contrast agents with high absorption coefficients in the optical window for tissue imaging, i.e. the near infrared (NIR) range between 680 and 950 nm. We herein report the photoacoustic properties of quinone-fused porphyrins inserted with different transition metals as new highly promising candidates. These dyes exhibit intense NIR absorption, a lack of fluorescence emission, and PA sensitivity in concentrations below 3 nmol mL. In this context, the highest PA signal was obtained with a Zn(ii) inserted dye. Furthermore, this dye was stable in blood serum and free thiol solution and exhibited negligible cell toxicity. Additionally, the Zn(ii) probe could be detected with an up to 3.2 fold higher PA intensity compared to the clinically most commonly used PA agent, ICG. Thus, further exploration of the 'quinone-fusing' approach to other chromophores may be an efficient way to generate highly potent PA agents that do not fluoresce and shift their absorption into the NIR range.
dc.description.sponsorshipFinancial support from the Excellence Initiative of the German federal and state governments through the I3TM Seed Fund Program and technical support from Fujifilm Visualsonics Inc (Drs Jithin Jose and Katrin Suppelt) are acknowledged. The authors particularly thank Drs Thomas Reiner, Jan Grimm and Moritz Kircher for their helpful discussions and support.
dc.publisherRoyal Society of Chemistry (RSC)
dc.relation.urlhttp://pubs.rsc.org/en/Content/ArticleLanding/2017/SC/C7SC01369H#!divAbstract
dc.rightsThis Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.titleQuinone-fused porphyrins as contrast agents for photoacoustic imaging
dc.typeArticle
dc.contributor.departmentChemical Science Program
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalChem. Sci.
dc.eprint.versionPublisher's Version/PDF
dc.contributor.institutionInstitute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, Aachen, D-52074, , Germany
dc.contributor.institutionInstitute for Experimental Molecular Imaging, University Clinic, RWTH Aachen University, Pauwelstraße 30, Aachen, D-52074, , , Germany
dc.contributor.institutionDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, , United States
dc.contributor.institutionInstitute of Organic Chemistry, University of Innsbruck, Innrain 80-82, Innsbruck, A6020, , Austria
kaust.personRueping, Magnus
refterms.dateFOA2018-06-14T05:19:10Z


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This Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
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