Quinone-fused porphyrins as contrast agents for photoacoustic imaging
Type
ArticleAuthors
Banala, SrinivasFokong, Stanley
Brand, Christian
Andreou, Chrysafis
Kräutler, Bernhard
Rueping, Magnus

Kiessling, Fabian
KAUST Department
Chemical Science ProgramKAUST Catalysis Center (KCC)
Physical Science and Engineering (PSE) Division
Date
2017Permanent link to this record
http://hdl.handle.net/10754/625873
Metadata
Show full item recordAbstract
Photoacoustic (PA) imaging is an emerging non-invasive diagnostic modality with many potential clinical applications in oncology, rheumatology and the cardiovascular field. For this purpose, there is a high demand for exogenous contrast agents with high absorption coefficients in the optical window for tissue imaging, i.e. the near infrared (NIR) range between 680 and 950 nm. We herein report the photoacoustic properties of quinone-fused porphyrins inserted with different transition metals as new highly promising candidates. These dyes exhibit intense NIR absorption, a lack of fluorescence emission, and PA sensitivity in concentrations below 3 nmol mL. In this context, the highest PA signal was obtained with a Zn(ii) inserted dye. Furthermore, this dye was stable in blood serum and free thiol solution and exhibited negligible cell toxicity. Additionally, the Zn(ii) probe could be detected with an up to 3.2 fold higher PA intensity compared to the clinically most commonly used PA agent, ICG. Thus, further exploration of the 'quinone-fusing' approach to other chromophores may be an efficient way to generate highly potent PA agents that do not fluoresce and shift their absorption into the NIR range.Citation
Banala S, Fokong S, Brand C, Andreou C, Kräutler B, et al. (2017) Quinone-fused porphyrins as contrast agents for photoacoustic imaging. Chem Sci 8: 6176–6181. Available: http://dx.doi.org/10.1039/c7sc01369h.Sponsors
Financial support from the Excellence Initiative of the German federal and state governments through the I3TM Seed Fund Program and technical support from Fujifilm Visualsonics Inc (Drs Jithin Jose and Katrin Suppelt) are acknowledged. The authors particularly thank Drs Thomas Reiner, Jan Grimm and Moritz Kircher for their helpful discussions and support.Publisher
Royal Society of Chemistry (RSC)Journal
Chem. Sci.ae974a485f413a2113503eed53cd6c53
10.1039/c7sc01369h
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