The papers on DNA repair systems in this issue grew out of a highly successful conference on International Workshop on Dynamic DNA and RNA Structures in Damage Responses & Cancer in 2016 in Cancun, Mexico sponsored by Fusion Conferences. I acknowledge that I learned much from this conference and the papers in this volume, and apologize for my focus on the limited associated literature with which I am most familiar which resulted in many outstanding papers not being noted. I thank all the attending researchers for contributing both insights and discussions on this topic during the meeting that are reflected in these papers. I am grateful to co-chair Tom Blundell for his many contributions to the intellectual and organizational aspects needed to make the conference and these papers an outstanding success. I am grateful to the community of external peer reviewers, who ensured vigorous assessment and improvement of submitted manuscripts. I gratefully acknowledge my funding by the National Institutes of Health (P01 CA092584), KAUST (CRG3), the Cancer Prevention and Research Institute of Texas (RR140052), and a Robert A. Welch Chemistry Chair for our efforts to understand DNA damage responses.