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    Small-bubble transport and splitting dynamics in a symmetric bifurcation

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    Type
    Article
    Authors
    Qamar, Adnan
    Warnez, Matthew
    Valassis, Doug T.
    Guetzko, Megan E.
    Bull, Joseph L.
    KAUST Department
    Water Desalination and Reuse Research Center (WDRC)
    Date
    2017-06-28
    Online Publication Date
    2017-06-28
    Print Publication Date
    2017-08-18
    Permanent link to this record
    http://hdl.handle.net/10754/625646
    
    Metadata
    Show full item record
    Abstract
    Simulations of small bubbles traveling through symmetric bifurcations are conducted to garner information pertinent to gas embolotherapy, a potential cancer treatment. Gas embolotherapy procedures use intra-arterial bubbles to occlude tumor blood supply. As bubbles pass through bifurcations in the blood stream nonhomogeneous splitting and undesirable bioeffects may occur. To aid development of gas embolotherapy techniques, a volume of fluid method is used to model the splitting process of gas bubbles passing through artery and arteriole bifurcations. The model reproduces the variety of splitting behaviors observed experimentally, including the bubble reversal phenomenon. Splitting homogeneity and maximum shear stress along the vessel walls is predicted over a variety of physical parameters. Small bubbles, having initial length less than twice the vessel diameter, were found unlikely to split in the presence of gravitational asymmetry. Maximum shear stresses were found to decrease exponentially with increasing Reynolds number. Vortex-induced shearing near the bifurcation is identified as a possible mechanism for endothelial cell damage.
    Citation
    Qamar A, Warnez M, Valassis DT, Guetzko ME, Bull JL (2017) Small-bubble transport and splitting dynamics in a symmetric bifurcation. Computer Methods in Biomechanics and Biomedical Engineering 20: 1182–1194. Available: http://dx.doi.org/10.1080/10255842.2017.1340466.
    Sponsors
    This research has been funded by NIH [grant number RO1EB006467].
    Publisher
    Informa UK Limited
    Journal
    Computer Methods in Biomechanics and Biomedical Engineering
    DOI
    10.1080/10255842.2017.1340466
    Additional Links
    http://www.tandfonline.com/doi/full/10.1080/10255842.2017.1340466
    ae974a485f413a2113503eed53cd6c53
    10.1080/10255842.2017.1340466
    Scopus Count
    Collections
    Articles; Water Desalination and Reuse Research Center (WDRC)

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