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    Fabrication of highly modulable fibrous 3D extracellular microenvironments

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    Type
    Article
    Authors
    Zhang, Xixiang cc
    Han, Fangfei
    Syed, Ahad
    Bukhari, Ebtihaj
    Siang, Basil Chew Joo
    Yang, Shan
    Zhou, BingPu
    Wen, Wei-jia
    Jiang, Dechen
    KAUST Department
    Biological and Environmental Sciences and Engineering (BESE) Division
    Material Science and Engineering Program
    Nanofabrication Core Lab
    Operations and Services
    Optical Lab
    Physical Science and Engineering (PSE) Division
    Date
    2017-06-13
    Online Publication Date
    2017-06-13
    Print Publication Date
    2017-09
    Permanent link to this record
    http://hdl.handle.net/10754/625609
    
    Metadata
    Show full item record
    Abstract
    Three-dimensional (3D) in vitro scaffolds that mimic the irregular fibrous structures of in vivo extracellular matrix (ECM) are critical for many important biological applications. However, structural properties modulation of fibrous 3D scaffolds remains a challenge. Here, we report the first highly modulable 3D fibrous scaffolds self-assembled by high-aspect-ratio (HAR) microfibers. The scaffolds structural properties can be easily tailored to incorporate various physical cues, including geometry, stiffness, heterogeneity and nanotopography. Moreover, the fibrous scaffolds are readily and accurately patterned on desired locations of the substrate. Cell culture exhibits that our scaffolds can elicit strong bidirectional cell-material interactions. Furthermore, a functional disparity between the two-dimensional substrate and our 3D scaffolds is identified by cell spreading and proliferation data. These results prove the potential of the proposed scaffold as a biomimetic extracellular microenvironment for cell study.
    Citation
    Zhang X, Han F, Syed A, Bukhari EM, Siang BCJ, et al. (2017) Fabrication of highly modulable fibrous 3D extracellular microenvironments. Biomedical Microdevices 19. Available: http://dx.doi.org/10.1007/s10544-017-0187-y.
    Publisher
    Springer Nature
    Journal
    Biomedical Microdevices
    DOI
    10.1007/s10544-017-0187-y
    PubMed ID
    28608128
    Additional Links
    https://link.springer.com/article/10.1007%2Fs10544-017-0187-y
    ae974a485f413a2113503eed53cd6c53
    10.1007/s10544-017-0187-y
    Scopus Count
    Collections
    Nanofabrication Core Lab; Articles; Biological and Environmental Science and Engineering (BESE) Division; Imaging and Characterization Core Lab; Physical Science and Engineering (PSE) Division; Material Science and Engineering Program

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