Fabrication of highly modulable fibrous 3D extracellular microenvironments
Type
ArticleAuthors
Zhang, Xixiang
Han, Fangfei
Syed, Ahad
Bukhari, Ebtihaj
Siang, Basil Chew Joo
Yang, Shan
Zhou, BingPu
Wen, Wei-jia
Jiang, Dechen
KAUST Department
Biological and Environmental Sciences and Engineering (BESE) DivisionMaterial Science and Engineering Program
Nanofabrication Core Lab
Operations and Services
Optical Lab
Physical Science and Engineering (PSE) Division
Date
2017-06-13Online Publication Date
2017-06-13Print Publication Date
2017-09Permanent link to this record
http://hdl.handle.net/10754/625609
Metadata
Show full item recordAbstract
Three-dimensional (3D) in vitro scaffolds that mimic the irregular fibrous structures of in vivo extracellular matrix (ECM) are critical for many important biological applications. However, structural properties modulation of fibrous 3D scaffolds remains a challenge. Here, we report the first highly modulable 3D fibrous scaffolds self-assembled by high-aspect-ratio (HAR) microfibers. The scaffolds structural properties can be easily tailored to incorporate various physical cues, including geometry, stiffness, heterogeneity and nanotopography. Moreover, the fibrous scaffolds are readily and accurately patterned on desired locations of the substrate. Cell culture exhibits that our scaffolds can elicit strong bidirectional cell-material interactions. Furthermore, a functional disparity between the two-dimensional substrate and our 3D scaffolds is identified by cell spreading and proliferation data. These results prove the potential of the proposed scaffold as a biomimetic extracellular microenvironment for cell study.Citation
Zhang X, Han F, Syed A, Bukhari EM, Siang BCJ, et al. (2017) Fabrication of highly modulable fibrous 3D extracellular microenvironments. Biomedical Microdevices 19. Available: http://dx.doi.org/10.1007/s10544-017-0187-y.Publisher
Springer NatureJournal
Biomedical MicrodevicesPubMed ID
28608128Additional Links
https://link.springer.com/article/10.1007%2Fs10544-017-0187-yae974a485f413a2113503eed53cd6c53
10.1007/s10544-017-0187-y
Scopus Count
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