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dc.contributor.authorEl-Sepelgy, Osama
dc.contributor.authorBrzozowska, Aleksandra
dc.contributor.authorRueping, Magnus
dc.date.accessioned2017-10-03T12:49:26Z
dc.date.available2017-10-03T12:49:26Z
dc.date.issued2017-02-28
dc.identifier.citationEl-Sepelgy O, Brzozowska A, Rueping M (2017) Asymmetric Chemoenzymatic Reductive Acylation of Ketones by a Combined Iron-Catalyzed Hydrogenation-Racemization and Enzymatic Resolution Cascade. ChemSusChem 10: 1664–1668. Available: http://dx.doi.org/10.1002/cssc.201700169.
dc.identifier.issn1864-5631
dc.identifier.doi10.1002/cssc.201700169
dc.identifier.urihttp://hdl.handle.net/10754/625568
dc.description.abstractA general and practical process for the conversion of prochiral ketones into the corresponding chiral acetates has been realized. An iron carbonyl complex is reported to catalyze the hydrogenation-dehydrogenation-hydrogenation of prochiral ketones. By merging the iron-catalyzed redox reactions with enantioselective enzymatic acylations a wide range of benzylic, aliphatic and (hetero)aromatic ketones, as well as diketones, were reductively acylated. The corresponding products were isolated with high yields and enantioselectivities. The use of an iron catalyst together with molecular hydrogen as the hydrogen donor and readily available ethyl acetate as acyl donor make this cascade process highly interesting in terms of both economic value and environmental credentials.
dc.publisherWiley
dc.relation.urlhttp://onlinelibrary.wiley.com/doi/10.1002/cssc.201700169/full
dc.rightsThis is the peer reviewed version of the following article: Asymmetric Chemoenzymatic Reductive Acylation of Ketones Using a Combined Iron Catalyzed Hydrogenation-Racemization and Enzymatic Resolution Cascade, which has been published in final form at http://doi.org/10.1002/cssc.201700169. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.
dc.subjectcascade catalysis
dc.subjectchiral alcohols
dc.subjectenzyme
dc.subjectkinetic resolution
dc.subjectracemization
dc.titleAsymmetric Chemoenzymatic Reductive Acylation of Ketones by a Combined Iron-Catalyzed Hydrogenation-Racemization and Enzymatic Resolution Cascade
dc.typeArticle
dc.contributor.departmentChemical Science Program
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalChemSusChem
dc.eprint.versionPost-print
dc.contributor.institutionInstitute of Organic Chemistry; RWTH Aachen University; Landoltweg 1 52074 Aachen Germany
kaust.personRueping, Magnus
refterms.dateFOA2018-03-24T00:00:00Z


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