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dc.contributor.authorXia, Yening
dc.contributor.authorShen, Jizhou
dc.contributor.authorAlamri, Haleema
dc.contributor.authorHadjichristidis, Nikolaos
dc.contributor.authorZhao, Junpeng
dc.contributor.authorWang, Yucai
dc.contributor.authorZhang, Guangzhao
dc.date.accessioned2017-08-30T11:40:26Z
dc.date.available2017-08-30T11:40:26Z
dc.date.issued2017-08-24
dc.identifier.citationXia Y, Shen J, Alamri H, Hadjichristidis N, Zhao J, et al. (2017) Revealing the Cytotoxicity of Residues of Phosphazene Catalysts Used for Synthesis of Poly(ethylene oxide). Biomacromolecules. Available: http://dx.doi.org/10.1021/acs.biomac.7b00891.
dc.identifier.issn1525-7797
dc.identifier.issn1526-4602
dc.identifier.pmid28835095
dc.identifier.doi10.1021/acs.biomac.7b00891
dc.identifier.urihttp://hdl.handle.net/10754/625428
dc.description.abstractWe herein report a case study on the toxicity of residual catalyst in metal-free polymer. Eight-arm star-like poly(ethylene oxide)s were successfully synthesized via phosphazene-catalyzed ring-opening polymerization of ethylene oxide using sucrose as an octahydroxy initiator. The products were subjected to MTT assay using human cancer cell lines (MDA-MB-231 and A2780). Comparison between the crude and purified products clearly revealed that the residual phosphazenium salts were considerably cytotoxic regardless of the anionic species, and that the cytotoxicity of more bulky t-BuP4 salt was higher than that of t-BuP2 salt. Such results have therefore put forward the necessity for removal of the catalyst residues from PEO-based polymers synthesized through phosphazene catalysis for bio-related applications, and for the development of less or non-toxic organocatalysts for such polymers.
dc.description.sponsorshipJ. Zhao thanks the financial supports of National Natural Science Foundation of China (21674038, 21504024) and Fundamental Research Funds for Central Universities (2017ZD072). Y. Wang thanks the financial support of National Natural Science Foundation of China (51573176). H. Alamri and N. Hadjichristidis thank King Abdullah University of Science and Technology (KAUST) for financial support.
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttp://pubs.acs.org/doi/abs/10.1021/acs.biomac.7b00891
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acs.biomac.7b00891.
dc.titleRevealing the Cytotoxicity of Residues of Phosphazene Catalysts Used for Synthesis of Poly(ethylene oxide)
dc.typeArticle
dc.contributor.departmentKAUST Catalysis Center (KCC)
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Division
dc.contributor.departmentPolymer Synthesis Laboratory
dc.identifier.journalBiomacromolecules
dc.eprint.versionPost-print
dc.contributor.institutionFaculty of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, P. R. China
dc.contributor.institutionSchool of Life Sciences, University of Science and Technology of China, Hefei 230027, P. R. China
kaust.personAlamri, Haleema
kaust.personHadjichristidis, Nikolaos


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