Revealing the Cytotoxicity of Residues of Phosphazene Catalysts Used for Synthesis of Poly(ethylene oxide)
KAUST DepartmentKAUST Catalysis Center (KCC)
Physical Sciences and Engineering (PSE) Division
Polymer Synthesis Laboratory
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AbstractWe herein report a case study on the toxicity of residual catalyst in metal-free polymer. Eight-arm star-like poly(ethylene oxide)s were successfully synthesized via phosphazene-catalyzed ring-opening polymerization of ethylene oxide using sucrose as an octahydroxy initiator. The products were subjected to MTT assay using human cancer cell lines (MDA-MB-231 and A2780). Comparison between the crude and purified products clearly revealed that the residual phosphazenium salts were considerably cytotoxic regardless of the anionic species, and that the cytotoxicity of more bulky t-BuP4 salt was higher than that of t-BuP2 salt. Such results have therefore put forward the necessity for removal of the catalyst residues from PEO-based polymers synthesized through phosphazene catalysis for bio-related applications, and for the development of less or non-toxic organocatalysts for such polymers.
CitationXia Y, Shen J, Alamri H, Hadjichristidis N, Zhao J, et al. (2017) Revealing the Cytotoxicity of Residues of Phosphazene Catalysts Used for Synthesis of Poly(ethylene oxide). Biomacromolecules. Available: http://dx.doi.org/10.1021/acs.biomac.7b00891.
SponsorsJ. Zhao thanks the financial supports of National Natural Science Foundation of China (21674038, 21504024) and Fundamental Research Funds for Central Universities (2017ZD072). Y. Wang thanks the financial support of National Natural Science Foundation of China (51573176). H. Alamri and N. Hadjichristidis thank King Abdullah University of Science and Technology (KAUST) for financial support.
PublisherAmerican Chemical Society (ACS)
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