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dc.contributor.authorBhanja, Piyali
dc.contributor.authorMishra, Snehasis
dc.contributor.authorManna, Krishnendu
dc.contributor.authorMallick, Arijit
dc.contributor.authorDas Saha, Krishna
dc.contributor.authorBhaumik, Asim
dc.date.accessioned2017-08-30T11:40:25Z
dc.date.available2017-08-30T11:40:25Z
dc.date.issued2017-08-23
dc.identifier.citationBhanja P, Mishra S, Manna K, Mallick A, Das Saha K, et al. (2017) Covalent Organic Framework Material bearing Phloroglucinol Building Units as a Potent Anticancer Agent. ACS Applied Materials & Interfaces. Available: http://dx.doi.org/10.1021/acsami.7b07343.
dc.identifier.issn1944-8244
dc.identifier.issn1944-8252
dc.identifier.pmid28831795
dc.identifier.doi10.1021/acsami.7b07343
dc.identifier.urihttp://hdl.handle.net/10754/625421
dc.description.abstractCovalent organic frameworks (COFs) having periodicity in pores of nanoscale dimensions can be suitably designed for the organic building units bearing reactive functional groups at their surfaces. Thus, they are an attractive option as an anticancer agent to overcome the limitations of chemotherapy. Herein, we first report a new porous biodegradable nitrogen containing COF material, EDTFP-1 (ethylenedianiline-triformyl phloroglucinol), synthesized using 4,4'-ethylenedianiline and 2,4,6-triformylphloroglucinol via Schiff base condensation reaction. EDTFP-1 exhibited 3D-hexagonal porous structure with average pores of ca. 1.5 nm dimension. Here, we have explored the anti-cancer potentiality of EDTFP-1. Result demonstrated an enhanced cytotoxicity was observed against four cancer cells HCT 116, HepG2, A549, and MIA-Paca2 with significant lower IC50 on HCT116 cells. Additionally, EDTFP-1-induced cell death was associated with the characteristic apoptotic changes like cell membrane blebbing, nuclear DNA fragmentation, externalization of phosphatidylserine from the cell membrane followed by a loss of mitochondrial membrane potential as well as modulation of pro and anti-apoptotic proteins. Further, the result depicted a direct correlation between the generations of ROS with mitochondrial-dependant apoptosis through the involvement of p53 phosphorylation upon EDTFP-1 induction, suggesting this COF material is a novel chemotherapeutic agent for cancer treatment.
dc.description.sponsorshipPB thanks to CSIR, New Delhi for a senior research fellowship. AB wishes to thank DST, New Delhi for instrumental facilities through DST Unit on Nanoscience.
dc.publisherAmerican Chemical Society (ACS)
dc.relation.urlhttp://pubs.acs.org/doi/abs/10.1021/acsami.7b07343
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials & Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/acsami.7b07343.
dc.titleCovalent Organic Framework Material bearing Phloroglucinol Building Units as a Potent Anticancer Agent
dc.typeArticle
dc.contributor.departmentAdvanced Membranes and Porous Materials Research Center
dc.contributor.departmentPhysical Sciences and Engineering (PSE) Division
dc.identifier.journalACS Applied Materials & Interfaces
dc.eprint.versionPost-print
dc.contributor.institutionDepartment of Materials Science, Indian Association for the Cultivation of Science, Jadavpur, Kolkata – 700 032, India.
dc.contributor.institutionCancer & Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Kolkata-700032, India.
kaust.personMallick, Arijit


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