Covalent Organic Framework Material bearing Phloroglucinol Building Units as a Potent Anticancer Agent
Das Saha, Krishna
KAUST DepartmentAdvanced Membranes and Porous Materials Research Center
Physical Science and Engineering (PSE) Division
Online Publication Date2017-09-05
Print Publication Date2017-09-20
Permanent link to this recordhttp://hdl.handle.net/10754/625421
MetadataShow full item record
AbstractCovalent organic frameworks (COFs) having periodicity in pores of nanoscale dimensions can be suitably designed for the organic building units bearing reactive functional groups at their surfaces. Thus, they are an attractive option as an anticancer agent to overcome the limitations of chemotherapy. Herein, we first report a new porous biodegradable nitrogen containing COF material, EDTFP-1 (ethylenedianiline-triformyl phloroglucinol), synthesized using 4,4'-ethylenedianiline and 2,4,6-triformylphloroglucinol via Schiff base condensation reaction. EDTFP-1 exhibited 3D-hexagonal porous structure with average pores of ca. 1.5 nm dimension. Here, we have explored the anti-cancer potentiality of EDTFP-1. Result demonstrated an enhanced cytotoxicity was observed against four cancer cells HCT 116, HepG2, A549, and MIA-Paca2 with significant lower IC50 on HCT116 cells. Additionally, EDTFP-1-induced cell death was associated with the characteristic apoptotic changes like cell membrane blebbing, nuclear DNA fragmentation, externalization of phosphatidylserine from the cell membrane followed by a loss of mitochondrial membrane potential as well as modulation of pro and anti-apoptotic proteins. Further, the result depicted a direct correlation between the generations of ROS with mitochondrial-dependant apoptosis through the involvement of p53 phosphorylation upon EDTFP-1 induction, suggesting this COF material is a novel chemotherapeutic agent for cancer treatment.
CitationBhanja P, Mishra S, Manna K, Mallick A, Das Saha K, et al. (2017) Covalent Organic Framework Material bearing Phloroglucinol Building Units as a Potent Anticancer Agent. ACS Applied Materials & Interfaces. Available: http://dx.doi.org/10.1021/acsami.7b07343.
SponsorsPB thanks to CSIR, New Delhi for a senior research fellowship. AB wishes to thank DST, New Delhi for instrumental facilities through DST Unit on Nanoscience.
PublisherAmerican Chemical Society (ACS)
- Porous Polymer Bearing Polyphenolic Organic Building Units as a Chemotherapeutic Agent for Cancer Treatment.
- Authors: Bhanja P, Mishra S, Manna K, Das Saha K, Bhaumik A
- Issue date: 2018 Jan 31
- A Novel One-Dimensional Porphyrin-Based Covalent Organic Framework.
- Authors: Zhang M, Zheng R, Ma Y, Chen R, Sun X, Sun X
- Issue date: 2019 Sep 16
- Microfluidic-based Synthesis of Covalent Organic Frameworks (COFs): A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface.
- Authors: Abrishamkar A, Rodríguez-San-Miguel D, Rodríguez Navarro JA, Rodriguez-Trujillo R, Amabilino DB, Mas-Ballesté R, Zamora F, deMello AJ, Puigmarti-Luis J
- Issue date: 2017 Jul 10
- Elephantopus scaber induces apoptosis through ROS-dependent mitochondrial signaling pathway in HCT116 human colorectal carcinoma cells.
- Authors: Chan CK, Supriady H, Goh BH, Kadir HA
- Issue date: 2015 Jun 20
- Ultrathin Two-Dimensional Covalent Organic Framework Nanosheets: Preparation and Application in Highly Sensitive and Selective DNA Detection.
- Authors: Peng Y, Huang Y, Zhu Y, Chen B, Wang L, Lai Z, Zhang Z, Zhao M, Tan C, Yang N, Shao F, Han Y, Zhang H
- Issue date: 2017 Jun 28