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Hall effect biosensors with ultraclean graphene film for improved sensitivity of label-free DNA detection

dc.contributor.authorLoan, Phan Thi Kim
dc.contributor.authorWu, Dongqin
dc.contributor.authorYe, Chen
dc.contributor.authorLi, Xiaoqing
dc.contributor.authorTra, Vu Thanh
dc.contributor.authorWei, Qiuping
dc.contributor.authorFu, Li
dc.contributor.authorYu, Aimin
dc.contributor.authorLi, Lain-Jong
dc.contributor.authorLin, Cheng-Te
dc.date.accessioned2017-07-26T06:19:10Z
dc.date.available2017-07-26T06:19:10Z
dc.date.issued2017-07-19
dc.identifier.citationLoan PTK, Wu D, Ye C, Li X, Tra VT, et al. (2017) Hall effect biosensors with ultraclean graphene film for improved sensitivity of label-free DNA detection. Biosensors and Bioelectronics. Available: http://dx.doi.org/10.1016/j.bios.2017.07.045.
dc.identifier.issn0956-5663
dc.identifier.pmid28743083
dc.identifier.doi10.1016/j.bios.2017.07.045
dc.identifier.urihttp://hdl.handle.net/10754/625253
dc.description.abstractThe quality of graphene strongly affects the performance of graphene-based biosensors which are highly demanded for the sensitive and selective detection of biomolecules, such as DNA. This work reported a novel transfer process for preparing a residue-free graphene film using a thin gold supporting layer. A Hall effect device made of this gold-transferred graphene was demonstrated to significantly enhance the sensitivity (≈ 5 times) for hybridization detection, with a linear detection range of 1 pM – 100nM for DNA target. Our findings provide an efficient method to boost the sensitivity of graphene-based biosensors for DNA recognition.
dc.description.sponsorshipThe authors are grateful for the financial support by the National Natural Science Foundation of China (51573201, 51501209, 201675165 and 21475033), Program for International S&T Cooperation Projects of the Ministry of Science and Technology of China (2015DFA50760), Public Welfare Project of Zhejiang Province (2016C31026), Science and Technology Major Project of Ningbo (2014S10001, 2016B10038 and 2016S1002), and International S&T Cooperation Program of Ningbo (2015D10003 and 2017D10016) for financial support. We also thank the Chinese Academy of Science for Hundred Talents Program, Chinese Central Government for Thousand Young Talents Program, 3315 Program of Ningbo, The Key Technology of Nuclear Energy (CAS Interdisciplinary Innovation Team, 2014), and Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 103.01–2015.98.
dc.publisherElsevier BV
dc.relation.urlhttp://www.sciencedirect.com/science/article/pii/S095656631730492X
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in Biosensors and Bioelectronics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biosensors and Bioelectronics, [, , (2017-07-19)] DOI: 10.1016/j.bios.2017.07.045 . © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectGraphene biosensors
dc.subjectDNA hybridization
dc.subjectHall effect measurement
dc.subjectultraclean surface
dc.subjectgold-transfer method
dc.titleHall effect biosensors with ultraclean graphene film for improved sensitivity of label-free DNA detection
dc.typeArticle
dc.contributor.departmentMaterial Science and Engineering Program
dc.contributor.departmentPhysical Science and Engineering (PSE) Division
dc.identifier.journalBiosensors and Bioelectronics
dc.eprint.versionPost-print
dc.contributor.institutionPhysics Department, School of Education, Can Tho University, Can Tho City, Vietnam
dc.contributor.institutionKey Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, P.R. China
dc.contributor.institutionUniversity of Chinese Academy of Sciences, 19 A Yuquan Rd., Shijingshan District, Beijing 100049, P.R. China
dc.contributor.institutionSchool of Materials Science and Engineering, Central South University, Changsha 410083, P. R. China
dc.contributor.institutionCollege of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, P. R. China
dc.contributor.institutionDepartment of Chemistry and Biotechnology, Faculty of Science, Engineering and Technology, Swinburne University of Technology, Melbourne, 3122 Australia
kaust.personLi, Lain-Jong
dc.date.published-online2017-07-19
dc.date.published-print2018-01


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